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ProteomicsSolute carrier family 12 member 2 as a proteomic and histological biomarker of dysplasia and neoplasia in ulcerative colitis
Ulcerative colitis (UC) patients have a greater risk of developing colorectal cancer through inflammation-dysplasia-carcinoma sequence of transformation. The histopathological diagnosis of dysplasia is therefore of critical clinical relevance, but dysplasia may be difficult to distinguish from infla...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD018679 | Pride
Dysplasia associated to inflammation Colorectal neoplasia Label-free proteomics 
TranscriptomicsTranscriptome analysis in human kidney to investigate whether fibrosis with inflammation at one year post transplant predicts transplant functional decline
We previously observed reduced graft survival for kidney transplants having interstitial fibrosis with subclinical inflammation, but not fibrosis alone, on 1-year protocol biopsy. The current study aimed to determine whether fibrosis with inflammation at 1 year is associated with renal functional de...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-22459 | biostudies-arrayexpress
TranscriptomicsGenetic architecture of murine skin inflammation and tumor susceptibility
Gene expression in self-renewing epithelial tissues is controlled by cis- and trans-activating regulatory factors that mediate responses to exogenous agents capable of causing tissue damage, infection, inflammation, or tumorigenesis. We used network construction methods to analyze the genetic archi...
ORGANISM(S): Mus musculus 
2008-12-31 | E-GEOD-12248 | biostudies-arrayexpress
TranscriptomicsNOD2-dependent licensing of the microbiota predispose to transmissible inflammation and tumorigenesis in the colon.
Instability in the composition of gut bacterial communities, referred as dysbiosis, has been associated with important human intestinal disorders such as CrohnM-bM-^@M-^Ys disease and colorectal cancer. Here, we show that dysbiosis coupled to Nod2 or Rip2 deficiency suffices to cause an increased ri...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-32421 | biostudies-arrayexpress
MetabolomicsMulti-omics reveals taurine-mediated rumen microbial remodeling mitigates high-starch-diet-induced systemic inflammation and oxidative stress in fattening cattle

Background: With the pursuit of rapid intramuscular fat deposition in beef cattle, basal diets have increasingly shifted toward grain-based, energy-dense formulations. However, high-starch dietary regimens may induce host metabolic dysregulation, which is closely linked to both ruminal microbial ...

2025-09-25 | MTBLS13041 | MetaboLights
TranscriptomicsTherapeutic interference with mTorc1 restricts inflammation-associated and Stat3-dependent gastro-intestinal tumourigenesis in mice
Gp130 receptor engagement on neoplastic cells provides a link by which an inflammatory microenvironment facilitates tumour promotion. Although hyperactivation of the gp130-dependent Stat3 signalling node is commonly observed in solid tumours, Stat3 remains a challenging therapeutic target. To mimic ...
ORGANISM(S): Mus musculus 
2013-01-29 | E-GEOD-35808 | biostudies-arrayexpress
GenomicsAntigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis [scData]
Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis [scData]
PRJNA961775 | ENA
TranscriptomicsExpression data for the different phases of ulcerative colitis-associated carcinogenesis in a mouse model
Nonresolving inflammation is correlated to carcinogenesis. Ulcerative colitis-associated colorectal cancer (UC-CRC), one of the typical carcinoma generated by inflammation that cannot be resolved properly, has been widely believed to involve a multistep process contains M-bM-^@M-^\inflammation-dyspl...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-31106 | biostudies-arrayexpress
TranscriptomicsNuclear receptor, RORa plays a critical role in obesity-associated inflammation, hepatic steatosis, and insulin resistance
We demonstrated that RORa-deficient staggerer mice (RORasg/sg) fed with a high fat diet (HFD) showed reduced adiposity and hepatic triglyceride levels compared to wild type (WT) littermates and were resistant to the development of hepatic steatosis, adipose-associated inflammation, and insulin resis...
ORGANISM(S): Mus musculus 
2011-04-30 | E-GEOD-23736 | biostudies-arrayexpress
TranscriptomicsNOD2 transmissible microbiota predispose WT mice to inflammation
Instability in the composition of gut bacterial communities, referred as dysbiosis, has been associated with important human intestinal disorders such as Crohn’s disease and colorectal cancer. Our data showed that Nod2-mediated risk of intestinal inflammation in colitis model is communicable to WT m...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-36481 | biostudies-arrayexpress
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