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ProteomicsDystrophin domains R4-15 and R20-23
Goal was to assess protein linkers between microtubules and dystrophin (specifically dystrophin regions R4-15 and R20-23). Two paired 10-plex TMT experiments were used to compare sixteen unique Dystrophin Glycoprotein Complex (or microtubule) enrichments (four genotypes, each with n=4) plus four poo...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-21 | PXD021088 | Pride
Micro-dystrophin Dystrophin glycoprotein complex Mice Dystrophin Microtubules 
TranscriptomicsHistone deacetylase 4 represses dystrophin-glycoprotein (DGC) complex expression
Dysfunction of the dystrophin-glycoprotein complex (DGC) is a frequent cause of hereditary forms of muscular dystrophy. Although DGC function in maintaining skeletal muscle integrity has been well characterized, little is known about how the DGC complex is coordinately regulated at the transcription...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-10678 | biostudies-arrayexpress
ProteomicsA signaling hub of insulin receptor dystrophin glycoprotein complex and plakoglobin regulates muscle size
Signaling through the insulin receptor governs central physiological functions related to cell growth and metabolism. Here we show by tandem native protein complex purification approach and super-resolution STED microscopy that insulin receptor activity requires association with the fundamental stru...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-19 | PXD016989 | Pride
Dystrophin Plakoglobin Insulin receptor 
TranscriptomicsHistone deacetylase 4 represses dystrophin-glycoprotein (DGC) complex expression
Dysfunction of the dystrophin-glycoprotein complex (DGC) is a frequent cause of hereditary forms of muscular dystrophy. Although DGC function in maintaining skeletal muscle integrity has been well characterized, little is known about how the DGC complex is coordinately regulated at the transcription...
ORGANISM(S): Mus musculus 
2008-03-25 | GSE10678 | GEO
GenomicsSignaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila
Signaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila
PRJNA926602 | ENA
GenomicsMus musculus
Histone deacetylase 4 represses dystrophin-glycoprotein (DGC) complex expression
PRJNA107661 | ENA
UnknownThe role of the dystrophin glycoprotein complex in muscle cell mechanotransduction.
Not available
S-EPMC9515174 | biostudies-literature
UnknownDystrobrevin increases dystrophin's binding to the dystrophin-glycoprotein complex and provides protection during cardiac stress.
Not available
S-EPMC4271192 | biostudies-literature
UnknownDystrophin insufficiency causes selective muscle histopathology and loss of dystrophin-glycoprotein complex assembly in pig skeletal muscle.
Not available
S-EPMC3963011 | biostudies-literature
TranscriptomicsSignaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila
Deficiencies in the human dystrophin glycoprotein complex (DGC), which links the extracellular matrix with the intracellular cytoskeleton, cause muscular dystrophies, a group of incurable disorders associated with heterogeneous muscle, brain and eye abnormalities. Stresses such as nutrient deprivati...
ORGANISM(S): Drosophila melanogaster 
2023-01-31 | GSE223505 | GEO
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