Sort   by:  
 Page size 
TranscriptomicsDeterminants of sensitivity to DZNep induced apoptosis in multiple myeloma cells
The 3-Deazaneplanocin A (DZNep), one of S-adenosylhomocysteine (AdoHcy) hydrolase inhibitors, has shown antitumor activities in a broad range of solid tumors and acute myeloid leukemia. Here, we examined its effects on multiple myeloma (MM) cells and found that, at 500 nM, it potently inhibited grow...
ORGANISM(S): Homo sapiens 
2011-07-04 | E-GEOD-26921 | biostudies-arrayexpress
TranscriptomicsThe S-adenosyl-homosteine hydrolase inhibitor DZNeP unspecifically affects histone methylation patterns in embryos and results in developmental aberrations
3-deazaneplanocin A (DZNeP) is a promising cancer drug affecting the methylation status of histone lysine residues. To investigate the specificity and mode of action of DZNeP, zebrafish embryos displaying high histone methyltransferase activity were cultured with DZNeP and histone methylation (H3K4m...
ORGANISM(S): Danio rerio 
2014-11-21 | E-GEOD-53209 | biostudies-arrayexpress
TranscriptomicsDMSO control and DZNep treated MOLM-14 cells
We demonstrated that 3-Deazaneplanocin A (DZNep), a histone methyltransferase inhibitor, induce robust apoptosis in AML cells through increased ROS production and ER stress. We identified a core gene signature including TXNIP, a major redox control molecule which is crucial in DZNep-induced apoptosi...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-30315 | biostudies-arrayexpress
TranscriptomicsEffect of butyrate and DZNep on hESC HSF-6
In order to recover nuclei with two active X chromosomes (class I), we developed a reprogramming strategy by supplementing hESC media with the small molecules sodium butyrate, and 3-deazaneplanocin A (DZNep). In order to determine how B+D affects global gene expression, we performed microarray anal...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-33864 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of DZNep treated B cell Lymphoma cell line Jeko-1
Jeko-1 cells were culture with or without PRC2 inhibitor 3-deazaneplanocin A (DZNep)(1uM) for 72hrs. We used TaqManM-BM-. Human MicroRNA Array to quantitate miRNA expression profile regulated by PRC2. qPCR miRNA expression profiling.
ORGANISM(S): Homo sapiens 
2012-08-11 | E-GEOD-40019 | biostudies-arrayexpress
ProteomicsConcomitant targeting of viral and host methyltransferases is essential for attenuating SARS-CoV-2
LC-MS/MS based investigation of protein abundance changes, induced by DZNep treatment in A549-ACE2 cell line (0.75 uM DZNep, vehicle PBS; 6h pre-treatment, harvested 24 h.p.i. with mock/SARS-CoV/SARS-CoV-2 at MOI 3) or primary human bronchial epithelial cells (NHBEs) (1.5 uM DZNep, vehicle PBS; 6h p...
ORGANISM(S): Homo sapiens (Human) 
2022-06-28 | PXD034361 | Pride
Dznep Sars-cov-2 A549 Nhbe Tubercidin A549-ace2 
TranscriptomicsGenome-wide analysis of high glucose and DZNep (EZH2 inhibitor) induced gene expression by mouse podocytes
Analysis of DZNep-induced gene expression changes in cultured podocytes. The hypothesis tested in the present study was that DZnep ultimately augments Txnip expression, increasing oxidative stress in podocytes. These results provide important information on the response of podocytes to histone methy...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-60038 | biostudies-arrayexpress
TranscriptomicsshRNA profiling of human DZNep-treated glioblastoma multiforme cancer stem cells
Overexpression of the Polycomb group protein Enhancer of Zeste Homolog 2 (EZH2) occurs in diverse malignancies, including prostate cancer, breast cancer, and glioblastoma multiforme (GBM) (1). Based on its ability to modulate transcription of key genes implicated in cell cycle control, DNA repair...
ORGANISM(S): Homo sapiens 
2009-12-14 | E-GEOD-18150 | biostudies-arrayexpress
GenomicsVitamin C promotes anti-leukemia of DZNep in Acute Myeloid Leukemia
Vitamin C promotes anti-leukemia of DZNep in Acute Myeloid Leukemia
PRJNA792424 | ENA
GenomicsTranscriptomic effects of EZH2 inhibition by DZNep in VEGF-stimulated HUVECs
Transcriptomic effects of EZH2 inhibition by DZNep in VEGF-stimulated HUVECs
PRJNA1371988 | ENA
Sort   by:  
 Page size