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MetabolomicsMaternal lipid mobilization is essential for embryonic development in a key malaria vector
Lipid metabolism is an essential component in reproductive physiology. While lipid mobilization has been implicated in the growth of Plasmodium falciparum malaria parasites in their Anopheles vectors, the role of this process in the reproductive biology of these mosquitoes remains elusive. Here, we ...
2024-11-05 | MTBLS9881 | MetaboLights
MetabolomicsContribution of fungal microbiome to intestinal physiology, early-life immune development and mucosal inflammation in mice
The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development is well established, the role of fungi remains to be determined. Here, we use germ-free mice colonized with defined species of bacteria, fun...
2022-01-14 | MTBLS1679 | MetaboLights
MetabolomicsThe functional role of OGDH for maintaining mitochondrial respiration and identity of primed human embryonic stem cells

Human embryonic stem cells (hESCs) can self-renew infinitely or differentiate into the 3 germ layer lineages in vitro with certain cues, holding great promise to model early human embryo development ex vivo. It is wildly accepted that hESCs take advantage of both glycolysis and ...

2022-03-03 | MTBLS4223 | MetaboLights
TranscriptomicsAlternative splicing is frequent during early embryonic development in mouse
Background Alternative splicing is known to increase the complexity of mammalian transcriptomes since nearly all mammalian genes express multiple pre-mRNA isoforms. However, our knowledge of the extent and function of alternative splicing in early embryonic development is based mainly on a few isola...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21971 | biostudies-arrayexpress
ProteomicsIncreased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition
Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease. However, the progressive detrimental remodeling processes that relate altered blood flow...
ORGANISM(S): Gallus Gallus (ncbitaxon:9031) 
2019-07-17 | MSV000084103 | MassIVE
TranscriptomicsTranscriptomic profiling of bovine IVF embryos revealed candidate genes and pathways involved in early embryonic development
Using microarrays, genome-wide RNA expression was profiled and compared for in vitro fertilization (IVF) - derived blastocysts and embryos undergoing degenerative development up to the same time point. Surprisingly similar transcriptomic profiles were found in degenerative embryos and blastocysts. N...
ORGANISM(S): Bos taurus 
2010-10-28 | E-GEOD-24936 | biostudies-arrayexpress
TranscriptomicsPolycomb function during oogenesis is required for mouse early embryonic development
This SuperSeries is composed of the following subset Series: GSE23033: Polycomb function during oogenesis is required for mouse early embryonic development (germinal vesicle oocytes) GSE28710: Polycomb function during oogenesis is required for mouse early embryonic development (2-cell embryos) Refer...
ORGANISM(S): Mus musculus 
2012-05-06 | E-GEOD-28711 | biostudies-arrayexpress
ProteomicsAhR interactome in early embryonic development
The transcriptional program of early embryonic development is tightly regulated by a set of well-defined transcription factors that suppress premature expression of differentiation genes and sustain the pluripotent identity. It is generally accepted that this program can be perturbed by environmenta...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-26 | PXD006089 | Pride
Nurd Ahr Interactome Environmental pollutants Embryonic development 
TranscriptomicsTranscription profiling of bovine early embryonic development in vivo using a bovine developmental array
Transcript abundance profiling analysis of bovine early embryonic development in vivo using a bovine developmental array.
ORGANISM(S): Bos taurus 
2009-06-01 | E-MEXP-2075 | biostudies-arrayexpress
TranscriptomicsPolycomb function during oogenesis is required for mouse early embryonic development (germinal vesicle oocytes)
In mammals, totipotent pre-implantation embryos are formed by fusion of highly differentiated oocytes and spermatozoa. Acquisition of totipotency concurs with remodeling of chromatin states of parental genomes (M-bM-^@M-^\epigenetic reprogrammingM-bM-^@M-^]), changes in maternally contributed transc...
ORGANISM(S): Mus musculus 
2012-05-06 | E-GEOD-23033 | biostudies-arrayexpress
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