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TranscriptomicsTranscription profiling of R1 embryonic stem cells treated with :to DMSO and retinoic acid vs control
Comparison of R1 embryonic stem cells response to DMSO and retinoic acid and control
ORGANISM(S): Mus musculus 
2006-10-27 | E-MEXP-412 | biostudies-arrayexpress
TranscriptomicsSAGE Libraries from Highly Purified Mouse Hematopoietic Stem Cells from the E14.5 Fetal Liver and Adult Bone Marrow
Recent improvements in the development of methods for isolating functionally validated populations of nearly pure (>20%) murine hematopoietic stem cells (HSCs) have made it possible to analyze the molecular basis of the properties of these cells with increased precision. One intriguing feature of HS...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-13243 | biostudies-arrayexpress
TranscriptomicsDistinct Stromal Cell Factor Combinations Can Separately Control Hematopoietic Stem Cell Survival, Proliferation and Self-Renewal
Hematopoietic stem cells (HSCs) are identified by their ability to sustain prolonged blood cell production in vivo, although recent evidence suggests that durable self-renewal (DSR) is shared by HSC subtypes with distinct self-perpetuating differentiation programs. Net expansions of DSR-HSCs occur i...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-57220 | biostudies-arrayexpress
TranscriptomicsTranscript Analysis of Human Mammary Cell Subsets using SAGE
Highly purified subpopulations of primitive bipotent and committed luminal progenitor cells as well as mature luminal and myoepithelial cells from normal human mammary tissue were isolated and compared their transcriptomes which were obtained using PCR-Long-SAGE technology. Keywords: mammary progeni...
ORGANISM(S): Homo sapiens 
2008-05-09 | E-GEOD-11387 | biostudies-arrayexpress
TranscriptomicsCell of origin in AML: Susceptibility to MN1-induced transformation is regulated by the MEIS1/abdB-like HOX protein complex
The molecular mechanism defining susceptibility of normal cells to oncogenic transformation may be a valuable therapeutic target. We characterized the cell of origin and its critical pathways in MN1 leukemias. Common myeloid (CMP), but not granulocyte-macrophage progenitors (CMP) could be transforme...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-22923 | biostudies-arrayexpress
TranscriptomicsGlobal gene expresion profile of phenotypically distinct human mammary epithelial subpopulations of various developmental age
To get molecular insight into age- and compartment-specific changes in telomere maintenance and associated properties in human mammary gland, we analyzed distinct subsets of normal human mammary epithelial cells. The cells were isolated by fluorescent activated cell sorting (FACS) directly from mam...
ORGANISM(S): Homo sapiens 
2013-07-26 | E-GEOD-37223 | biostudies-arrayexpress
GenomicsAffymetrix raw files - samples
Affymetrix 6.0 cel files
EGAD00010000158 | EGA
GenomicsIllumina raw files - samples
Illumina HT 12 IDATS
EGAD00010000160 | EGA
GenomicsZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
The telomeric amplicon at 8p12 is common in oestrogen receptor-positive (ER+) breast cancers. Array-CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within the minimal amplicon and was amplified predominantly in the Luminal B subtype. Amplification ...
EGAS00000000082 | EGA
TranscriptomicsDevelopmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells
Many normal adult tissues contain rare stem cells with extensive self-maintaining regenerative potential. During development, the stem cells of the hematopoietic and neural systems undergo intrinsically specified changes in their self-renewal potential. In the mouse, mammary stem cells with transpla...
ORGANISM(S): Mus musculus 
2013-08-13 | E-GEOD-46357 | biostudies-arrayexpress
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