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Proteomics,MultiomicsProteomics of EBV-infected lytic and refractory cells
Most humans are infected with Epstein-Barr virus (EBV), a cancer-causing virus. While EBV generally persists silently in B lymphocytes, periodic lytic (re-)activation of latent virus is central to its life cycle and to most EBV-related diseases. However, a substantial fraction of EBV-infected B cell...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079993 | MassIVE
MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
TranscriptomicsThe Epstein-Barr virus induced tumor suppressor miR-34a is growth promoting in EBV-infected B cells
Epstein-Barr virus (EBV) infection of primary human B cells drives their indefinite proliferation into lymphoblastoid cell lines (LCLs). B cell immortalization depends on expression of viral latency genes as well as the regulation of host genes. Given the important role of miRNAs in regulating fund...
ORGANISM(S): Homo sapiens 
2012-04-19 | E-GEOD-36926 | biostudies-arrayexpress
ProteomicsAutoreactive T Cells Recognize Unique MBP Peptides Naturally Presented by EBV-Infected B Cells and Multiple Sclerosis Brain Tissue
Epstein-Barr virus (EBV) is involved in causing and probably also perpetuating multiple sclerosis (MS). Among several mechanisms, how EBV may contribute, are transcriptome alterations including changes of antigen processing and preferential presentation of both viral and self-antigens. Here, we foun...
ORGANISM(S): Homo sapiens (Human) 
2026-06-19 | PXD068927 | Pride
Mbp Ebv-infected b-cells Human Lc-ms/ms 
TranscriptomicsInfection of naïve primary human B-lymphocytes with Epstein-Barr virus (EBV) – time course transcriptomic analysis in the pre-latent phase of viral infection
B cells from anonymous adenoid donors were isolated and sorted for naïve B cells, which were subsequently infected with a reference EBV strain (2089_B95-8) using a defined multiplicity of infection. Infection of resting B cells with EBV induces their activation, their proliferation, and subsequent i...
ORGANISM(S): Homo sapiens 
2019-07-01 | E-MTAB-7805 | biostudies-arrayexpress
TranscriptomicsInduction of interferon-stimulated genes on the IL-4 response axis by Epstein-Barr virus infected human B cells; relevance to cellular transformation.
Epstein-Barr virus (EBV) is an oncogenic virus that is associated with the pathogenesis of several human lymphoid malignancies, including Hodgkin's lymphoma. Infection of normal resting B cells with EBV results in activation to lymphoblasts that are phenotypically similar to those generated by physi...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-45829 | biostudies-arrayexpress
Proteomics Autoreactive T Cells Recognize Unique MBP Peptides Naturally Presented by EBV-Infected B Cells and Multiple Sclerosis Brain Tissue
Epstein-Barr virus (EBV) is involved in causing and probably also perpetuating multiple sclerosis (MS). Among several mechanisms, how EBV may contribute, are transcriptome alterations including changes of antigen processing and preferential presentation of both viral and self-antigens. Here, we foun...
ORGANISM(S): Homo sapiens (Human) 
2026-03-11 | PXD068488 | Pride
Multiple sclerosis Brain Ebv Immunopeptidomics B cells T cells 
GenomicsConcomitant Cytotoxic Effector Differentiation of CD4+ and CD8+ T Cells in Response to EBV-Infected B Cells
Concomitant Cytotoxic Effector Differentiation of CD4+ and CD8+ T Cells in Response to EBV-Infected B Cells
PRJNA852222 | ENA
Methylation profilingEpigenome analysis of B cell and B cells infected with Epstein-Barr virus (EBV)
Genome wide DNA methylation profiles of B cell and B cells infected with EBV (LCLs). The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in B cells and EBV infected B cells. Samples included 8 normal B cells witho...
ORGANISM(S): Homo sapiens 
2017-01-11 | GSE93373 | GEO
TranscriptomicsThe viral and cellular microRNA targetome in lymphoblastoid cell lines
Epstein-Barr virus (EBV) is a human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41437 | biostudies-arrayexpress
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