Sort   by:  
 Page size 
ProteomicsInfluenza-resolved mouse lung vs control LC-MS/MS
Project investigates lung extracellular matrix recovery after influenza infection. Influenza A strain APR8 was adminsitered intranasally. Infection caused transient weight loss which fully recovered by day 12. On day 21 post-infection (when mice were asymptomatic and fully recovered) lungs were harv...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-21 | PXD054592 | Pride
Influenza Recovery Mouse Lung Inflammation Lc-ms/ms 
ProteomicsNovel skin photoageing biomarkers of epidermis and dermis revealed by traditional relative quantification in combination with a novel peptide locational fingerprinting MPLF.
Human skin undergoes profound structural remodelling following chronic exposure to ultraviolet radiation (UVR) – photoageing - that is normally studied by comparing photoexposed and photoprotected skin sites. Whilst it is well established that the abundance and distribution of major dermal extracell...
ORGANISM(S): Homo sapiens (Human) 
2021-04-09 | PXD021194 | Pride
#skin #epidermis #dermis #biomarkers 
ProteomicsMass spectrometry detection of photodamage in human extracellular matrix assemblies
Photoageing in skin is commonly recognised by architectural remodelling of dermal extracellular matrix components. Mass spectrometry was previously used to identify tissue-specific patterns of fibrillin-1 and collagen VI peptide spectrum matches (PXD008450). This study aimed to determine if the same...
ORGANISM(S): Homo sapiens (Human) 
2020-01-30 | PXD015149 | Pride
Human Ecm Collagen vi Fibrillin Ultraviolet Microfibrils Lc-ms/ms 
ProteomicsTissue Microfibril Comparison - Structural and compositional diversity of fibrillin microfibrils in human tissues
Fibrillin microfibrils are large supramolecular ECM assemblies which play different functional roles in different tissues. We aim to compare the ultrastructure and biological composition of fibrillin microfibrils purified from human eye, skin and cultured dermal fibroblasts. This will allow us to un...
ORGANISM(S): Homo sapiens (Human) 
2018-02-16 | PXD008450 | Pride
Human Microfibril Afm Fibrillin Collagen Lc-ms/ms 
Sort   by:  
 Page size