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ProteomicsProteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature
The ovarian microenvironment becomes fibrotic and stiff with age due in part to increased stromal collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex network of hundreds of proteins, glycoproteins and glycans which are highly tissue specific and undergo pronounced...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-24 | MSV000091790 | MassIVE
TranscriptomicsECM-dependent gene expression in normal and tumor-derived mammary organoids
A critical step in metastasis is cancer cell dissemination. Dissemination and metastasis are associated with specific genetic changes and changes in extracellular matrix (ECM), but how these changes interact to enable dissemination remains unclear. Here we tested the importance of ECM to disseminat...
ORGANISM(S): Mus musculus 
2012-08-16 | E-GEOD-39173 | biostudies-arrayexpress
ProteomicsECM-enriched mouse lung - TMT-based quantitative mass spectrometry analysis was performed on ECM-enriched preparation from normal murine lung, bleomycin-induced fibrotic lung, primary tumors and lymph node metastasis isolated from the KrasG12D/+p53-/- mouse model of lung adenocarcinoma. Three independent samples were processed and analyzed for each condition. This study identified ECM signatures of normal and diseased lung tissue.
TMT-based quantitative mass spectrometry analysis was performed on ECM-enriched preparation from normal murine lung, bleomycin-induced fibrotic lung, primary tumors and lymph node metastasis isolated from the KrasG12D/+p53-/- mouse model of lung adenocarcinoma. Three independent samples were process...
ORGANISM(S): Mus musculus (Mouse) 
2017-06-21 | PXD003517 | Pride
Extraceullar matrix 
OtherExtracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Data from MASSIVE, MSV000078555. Experiment: D120204_CoN_2207, file: D120204_MGH_2207_OGE07_rafkt_ft8dt_cc_01.mzml. Published as part of BMC Cancer. 2014 Jul 18;14(1):518 . From the Abstract: {{i}} We have used enrichment of extracellular matrix (ECM) from human patient samples and proteomics to de...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310002460 | GPMDB
Resource Reanalysis 
OtherExtracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.
Data from Massive, MSV000078535. MDAMB23 experiment: D101003_MDAMB231_1_OGE, file: D101003_MDAMB231_1_OGE02_rafkt_ft8_cc_01.mzml. Published as part of Elife. 2014 Mar 11;3:e01308 . From the Abstract: {{i}} In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts...
ORGANISM(S): Homo_sapiens_viruses,mus_musculus_viruses, Human_female,mouse_female 
GPM32320002348 | GPMDB
Resource Reanalysis 
ProteomicsProteomic analysis of gastric cancero patient-derived tissue ECM
Gastric cancer (GC) is a highly heterogeneous disease regarding histologic features, genotypes, and molecular phenotypes. Here, we investigated extracellular matrix (ECM)-centric analysis, examining its association with histologic subtypes and patient prognosis in human gastric cancer. We performed ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-12 | MSV000093859 | MassIVE
ProteomicsQuantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer
The composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and restricting anti-tumour therapies through multiple mechanisms. The characterisation of differences in ECM co...
ORGANISM(S): Homo sapiens (Human) 
2023-06-16 | PXD041066 | Pride
Human Ecm Cancer Lung 
TranscriptomicsTranscription profiling by array of human breast epithelium and stroma in normal reduction mammoplasty and invasive breast cancer patients
The molecular basis of breast cancer invasion and metastasis is not well understood. Our objective was to analyze transcriptome differences between stromal and epithelial cells in normal breast tissue and invasive breast cancer to define the role stroma plays in invasion. Total RNA was isolated fr...
ORGANISM(S): Homo sapiens 
2009-03-07 | E-GEOD-10797 | biostudies-arrayexpress
ProteomicsProteomic profiling of the ECM of CD8-high (“hot’) and CD8-low (“cold”) subcutaneous murine pancreatic ductal adenocarcinomas
The goal of this project was to compare the extracellular matrix (ECM) composition – or matrisome – of CD8-high (“hot’) and CD8-low (“cold”) subcutaneous murine pancreatic ductal adenocarcinomas
ORGANISM(S): Mus musculus (Mouse) 
2026-04-30 | PXD060932 | Pride
Matrisome Pdac 
TranscriptomicsHuman Pancreatic CTCs Express the ECM Protein SPARC
Circulating Tumor Cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. To determine the relevance of ECM protein expression to human disease, CTCs were isolated from the blood of metastatic PDAC patients and subjected to singl...
ORGANISM(S): Homo sapiens 
2014-09-22 | E-GEOD-60407 | biostudies-arrayexpress
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