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ProteomicsQuantitative phosphoproteome of ecto-ATP synthase blockade in lung cancer cells
ATP synthase is crucial for ATP synthesis in living cells. Recently, ATP synthase was found not only in mitochondria but also on the extracellular surface, named as ectopic ATP synthase (ecto-ATP synthase). ATP synthase inhibitor is a potential drug candidate to fight cancer by blocking the ecto-ATP...
ORGANISM(S): Homo sapiens (Human) 
2015-11-06 | PXD000696 | Pride
Lung cancer cells Phosphoproteome Ecto-atp synthase 
ProteomicsTrafficking of Ectopic ATP Synthase via Mitochondrial Fission
Ectopic ATP synthase is a functional onco-protein increases cell proliferation when transported to plasma membrane of cancer cells. Our previous study performed large scale gene silencing screening indicated ER and mitochondrial transport pathways may lead to ectopic ATP synthase expression. Silenci...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD007036 | Pride
Ectopic atp synthases  proteome  protein trafficking  mitochondrial fission  image analysis 
ProteomicsThe Role of Microtubules in the Trafficking of Ectopic ATP Synthase
Adenosine triphosphate (ATP) synthase is located on the inner membrane of mitochondria which generate ATP for various cellular processes. Our previous studies showed that ATP synthases existed on plasma membrane of several types of cancer cells, which was defined as ectopic ATP synthase. However, th...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD006791 | Pride
Ectopic atp synthases  proteomic analysis  the trafficking of mitochondria  microtubule  kif5b  drp1 
ProteomicsPhosphoproteome of ecto-ATP synthase blockade in tumor xenograft tissues
ATP synthase is crucial for ATP synthesis in living cells. Recently, ATP synthase was found not only in mitochondria but also on the extracellular surface, named as ectopic ATP synthase (ecto-ATP synthase). ATP synthase inhibitor is a potential drug candidate to fight cancer by blocking the ecto-ATP...
ORGANISM(S): Homo sapiens (Human) 
2015-11-06 | PXD000701 | Pride
Phosphoproteome Tumor xenograft Ecto-atp synthase 
ProteomicsThe Function of Ectopic ATP Synthase in Extracellular Vesicles.
Ectopic adenosine triphosphate synthase (eATP synthase) was found on the cell surface to generate extracellular ATP in various cancer cells. Recently using proteomics approach, several reports identified ATP synthase in extracellular vesicles (EVs) which are important in cell-cell communications. Ho...
ORGANISM(S): Homo sapiens (Human) 
2023-05-22 | PXD014995 | Pride
Ectopic atp synthases  extracellular vesicles  proteomic analysis  serum depletion  human lymphoma jurkat t cells 
ProteomicsTemporal Phosphoproteome Dynamics Reveals the Role of ATP Synthase Inhibitor Citreoviridin in Gefitinib-resistant Lung Cancer Cells
Non-small cell lung cancer is the leading cause of cancer death worldwide. Gefitinib, epidermal growth factor receptor tyrosine kinase inhibitor, is the first-line treatment of NSCLC, however, many patients eventually become resistant and experience progressive disease. Therefore, development of eff...
ORGANISM(S): Homo sapiens (Human) 
2020-08-17 | PXD010767 | Pride
Lung cancer Ectopic atp synthase Gefitinib resistance Phosphoproteomics 
ProteomicsQuantitative phosphoproteomics reveals the temporal phosphorylation network regulated via mesenchymal stem cells in the tumor microenvironment
The tumor microenvironment (TME), which comprises cellular and noncellular components, is involved in the complex process of cancer development. Emerging evidence suggests that mesenchymal stem cells (MSCs), one of the vital regulators of the TME, foster tumor progression through paracrine secretion...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD029288 | Pride
C-fos Phosphoproteomics Tumor microenvironment Mesenchymal stem cell Ectopic atp synthase Mapk P2x7r 
ProteomicsTargeting the E2F1/GAS5/p53 Axis as a Potential Therapeutic Strategy for Gefitinib-Resistant Lung Cancer
Lung cancer is one of the most common and fatal cancer worldwide. There are two major types of lung cancer, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Recently, gefitinib, a small molecule, which target tyrosine kinase, has been regarded as the first-line treatment in NSCL...
ORGANISM(S): Homo sapiens (Human) 
2020-08-17 | PXD013139 | Pride
Lung cancer Ectopic atp synthase Lncrna-interactomics Gefitinib resistance 
UnknownQuantitative proteomic analysis of human lung tumor xenografts treated with the ectopic ATP synthase inhibitor citreoviridin.
Not available
S-EPMC3749231 | biostudies-literature
UnknownEctopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells.
Not available
S-EPMC10272197 | biostudies-literature
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