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ProteomicsYAP/TAZ drives ependymoma-like tumour formation in mice
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to drive brain tumour formation in mice. Neuron...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD018131 | Pride
Brain Mus musculus Tmt10plex Nlsyap5sa Ependymoma 
ProteomicsChemical Genetic Identification of Cyclin-G-associated kinase (GAK) Substrates Reveals its Role in Regulating Na+/K+-ATPase and Sipa1L1 in Neurons
Recent genetic evidence implicates the serine/threonine kinase cyclin G-associated kinase (GAK) as a Parkinson’s disease risk. However, its role in neuronal function and many downstream effectors remain unclear. Employing a chemical genetics method, we show here that the sodium potassium pump (Na+...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-07 | PXD011319 | Pride
Cyclin-g-associated kinase Sodium potassium pump Atp1a3 Gak 
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