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ProteomicsStructural proteomics defines a sequential priming mechanism for the progesterone receptor (XL-MS)
The progesterone receptor (PR) is a steroid-responsive nuclear receptor with two isoforms: PR-A and PR-B. Disruption of PR-A:PR-B signaling is associated with breast cancer through interactions with oncogenic co-regulatory proteins (CoRs). However, molecular details of isoform-specific PR-CoR intera...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD056360 | Pride
Xl-ms Progesterone receptor Crosslinking 
ProteomicsStructural proteomics defines a sequential priming mechanism for the progesterone receptor (HDX-MS)
The progesterone receptor (PR) is a steroid-responsive nuclear receptor with two isoforms: PR-A and PR-B. Disruption of PR-A:PR-B signaling is associated with breast cancer through interactions with oncogenic co-regulatory proteins (CoRs). However, molecular details of isoform-specific PR-CoR intera...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD056400 | Pride
Hydrogen-deuterium exchange Progesterone receptor Structural proteomics Hdx 
ProteomicsHDX-MS Analysis of RORg:RORE:SRC3 Complexes
The retinoic acid receptor-related orphan receptor γ (RORγ) is a ligand-dependent transcription factor that both underpins metabolic and immune functions and provides vantage to manipulate those processes pharmacologically. Despite its importance, our understanding of the ligand-dependent activities...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025765 | Pride
Protein-dna interaction Rorg Rorg response elements Hydrogen deuterium exchange mass spectrometry Protein-protein interaction Src3 
ProteomicsXL-MS of RORg:RORE:SRC3 Complexes
The retinoic acid receptor-related orphan receptor γ (RORγ) is a ligand-dependent transcription factor that both underpins metabolic and immune functions and provides vantage to manipulate those processes pharmacologically. Despite its importance, our understanding of the ligand-dependent activities...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025728 | Pride
Orphan nuclear receptor Dna binding Ligand binding Rorg Protein-protein interactions 
UnknownBiomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.
Not available
S-EPMC11862976 | biostudies-literature
UnknownCost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis.
Not available
S-EPMC12661845 | biostudies-literature
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10957483 | biostudies-literature
UnknownDuration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Not available
S-EPMC7616389 | biostudies-literature
UnknownAdding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Not available
S-EPMC7616360 | biostudies-literature
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