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ProteomicsLinking acetyl-CoA labelling and histone acetylation dynamics for accurate determination of acetylation rates via ordinary differential equations
To study complex biological systems, multi-omics methods have become an important tool. They integrate data from multiple biological layers, such as the metabolome and the proteome, to gain better insights of the processes happening. However, challenges remain both in sample preparation for measurem...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051487 | Pride
Human Lc-msms Acetylcoa Ptm Histone Acetylation Hek93t 
ProteomicsCombined Metabolic and Chemical (CoMetChem) labeling using stable isotopes
Histone acetylation is an important, reversible posttranslational protein modification and hallmark of epigenetic regulation. However, little is known about the dynamics of reversible hisotne acetylation, due to the lack of analytical methods that can capture site-specific acetylation and deacetylat...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD027338 | Pride
Lc-msms Stable isotopes Acetylation Histones 
ProteomicsThe proteome landscape of genome-wide genetic perturbations
Despite the massive research efforts of the post-genomics era, a significant fraction of genes remain without functional annotation. Proteomics holds the promise to close significant gaps, but has only recently reached the scalability and precision of genome-scale studies. Here we combine large-scal...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2022-08-15 | MSV000090136 | MassIVE
UnknownTXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
Not available
S-SCDT-10_1038-S44318-025-00608-9 | biostudies-other
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