Eif2a - OmicsDI

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Lipidomics Group Leibniz-Institute for analytical science – ISAS – e.V. Otto-Hahn-Straße 6b 44227 Dortmund, Germany (1)
Proteomics Unit, CNIC Madrid, Spain (1)
The Obstetrics & Gynecology Hospital of Fudan University, Shanghai, china (1)

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eIF2A regulates cell migration without overtly affecting translation

The RNA-binding protein eIF2A has been implicated in a variety of cellular processes including tumorigenesis. This role has been attributed to its function as alternative translation initiation factor. However, the mechanisms by which eIF2A regulates translation and its contribution to oncogenic tra...

ORGANISM(S): Homo sapiens (Human)

2025-08-05 | PXD055625 | Pride

eIF2A represses cell wall biogenesis gene expression in Saccharomyces cerevisiae

Translation initiation is a complex and highly regulated process that represents an important mechanism, controlling gene expression. eIF2A was proposed as an alternative initiation factor, however, its role and biological targets remain to be discovered. To further gain insight into the function of...

ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast)

2023-09-15 | PXD043985 | Pride

Saccharomyces cerevisiae Affinity purification Eif2a

Time-course SILAC proteomics to determine the response to WEE1i in RPE-1 WT vs EIF2A-KO RPE-1 cells

AZD1775 is an ATP-competitive inhibitor of WEE1 protein kinase. Inhibition of WEE1 causes hyperactivation of CDK1 and CDK2, which leads to premature mitosis and DNA replication stress. AZD1775 has been evaluated in patients with relapsed high grade serous ovarian cancer (HGSOC) and has shown promisi...

ORGANISM(S): Homo sapiens (Human)

2025-10-07 | PXD054741 | Pride

Human ovarian wee1 eif2a hgsoc

eIF2A regulates cell migration without overtly affecting translation

PRJNA1173846 | ENA

eIF2A regulates cell migration without overtly affecting translation [RIP-Seq]

PRJNA1173086 | ENA

The eIF2A knockout mouse.

Not available

S-EPMC5134716 | biostudies-literature

eIF2A regulates cell migration without overtly affecting translation [Ribo-Seq]

PRJNA1173087 | ENA