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TranscriptomicsTranscriptome of early postnatal brain development of eIF2B-R132H/R132H mutant mice relative to wild-types.
Genome-wide mRNA expression in brains of wild-type and eIF2B-R132H/R132H mutant mice (Geva et al., BRAIN 133 (8), 2010) profiled at postnatal (P) days 1, 18 and 21 to reflect the early proliferative stage prior to white matter establishment (P1) and the peak of oligodendrocye differentiation and mye...
ORGANISM(S): Mus musculus 
2011-11-14 | E-GEOD-32201 | biostudies-arrayexpress
GenomicseIF2B-capturing viral protein NSs suppresses the integrated stress response
eIF2B-capturing viral protein NSs suppresses the integrated stress response
PRJNA731488 | ENA
UnknownMutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease.
Not available
S-EPMC7948505 | biostudies-literature
ProteomicsMS-based identification of AcP10 interaction partners.
In times of cellular stress, such as during virus infections, the integrated stress response (ISR) blocks translation initiation through phosphorylation of the essential translation initiation factor eIF2. Phosphorylated eIF2 (p-eIF2) sequesters the eIF2-specific guanidine exchange factor (GEF) eIF2...
ORGANISM(S): Homo sapiens (Human) 
2020-07-24 | PXD011879 | Pride
Ap-ms Eif2 Bw10 Interactome Eif2b 
UnknownSugar phosphate activation of the stress sensor eIF2B.
Not available
S-EPMC8187479 | biostudies-literature
TranscriptomicsMaintenance of p-eIF2 alpha levels by the eIF2B complex is vital for colorectal cancer
Protein synthesis is an essential cellular process highly deregulated in multiple tumour types, where control of several translation factors is hijacked to benefit oncogenic growth. Here we show that colorectal cancer (CRC) is characterized specifically by elevated levels of phosphorylated eukaryoti...
ORGANISM(S): Homo sapiens 
2025-01-09 | GSE249128 | GEO
TranscriptomicseIF2B-capturing viral protein NSs suppresses the integrated stress response
Various stressors such as viral infection lead to the suppression of cap-dependent translation and the activation of the integrated stress response (ISR), since the stress-induced phosphorylated eukaryotic translation initiation factor 2 [eIF2(αP)] tightly binds to eIF2B to prevent it from exchangin...
ORGANISM(S): Homo sapiens 
2021-11-11 | GSE174764 | GEO
GenomicsMaintenance of p-eIF2 alpha levels by the eIF2B complex is vital for colorectal cancer
Maintenance of p-eIF2 alpha levels by the eIF2B complex is vital for colorectal cancer
PRJNA1047524 | ENA
UnknowneIF2B conformation and assembly state regulate the integrated stress response.
Not available
S-EPMC7990499 | biostudies-literature
UnknownNovel mechanisms of eIF2B action and regulation by eIF2α phosphorylation.
Not available
S-EPMC5714165 | biostudies-literature
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