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TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (mRNA)
The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has...
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72081 | biostudies-arrayexpress
TranscriptomicsEvaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Affymetrix]
The study investigated differential gene expression in primary mouse hepatocyte mRNA following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological ...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-57129 | biostudies-arrayexpress
TranscriptomicsThe immediate early gene product EGR1 and Polycomb Group proteins interact in epigenetic programming during chondrogenesis
Chondrogenic differentiation was induced in ATDC5 cells in the absence (RNAi) or presence of EGR1 (Early Growth Response Protein 1); RNA samples were collected at t=0, 2, 4.5, 8,16, 24, 72 hrs.
ORGANISM(S): Mus musculus 
2013-05-07 | E-MTAB-1464 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of lymphocytes from BRCA1-mutation carriers and controls in response to irradiation
Lymphocytes from 10 BRCA1-mutation carriers and 6 controls were cultured and irradiated with 10Gy. Additional 15 mutation carriers and 5 controls were subjected to the same treatment and scanned separately.
ORGANISM(S): Homo sapiens 
2018-10-31 | E-MTAB-982 | biostudies-arrayexpress
TranscriptomicsDifferences in gene expression profiles between human preimplantation embryos cultured in two different IVF culture media
Study question: Is gene expression in human preimplantation embryos affected by medium used for culturing embryos during an IVF treatment? Summary answer: Six days of in vitro culture of human preimplantation embryos resulted in a medium-dependent expression level of genes involved in apoptosis, pr...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-MTAB-3405 | biostudies-arrayexpress
TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72088 | biostudies-arrayexpress
UnknownThe Molecular Biology of Susceptibility to Post-Traumatic Stress Disorder: Highlights of Epigenetics and Epigenomics.
Not available
S-EPMC8509551 | biostudies-literature
UnknownTo Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers.
Not available
S-EPMC10049301 | biostudies-literature
UnknownPathway analysis of transcriptomic data shows immunometabolic effects of vitamin D.
Not available
S-EPMC5850959 | biostudies-literature
UnknownExploring pathway interactions in insulin resistant mouse liver.
Not available
S-EPMC3169508 | biostudies-literature
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