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ProteomicsProteases Shape the Chlamydomonas Secretome: Comparison to Classical Neuropeptide Processing Machinery
The recent identification of catalytically active peptidylglycine -amidating monooxygenase (PAM) in Chlamydomonas reinhardtii, a unicellular green alga, suggested the presence of a PAM-like gene and peptidergic signaling in the last eukaryotic common ancestor (LECA). Homologs of prototypical neurop...
ORGANISM(S): Chlamydomonas reinhardtii 
2019-07-30 | PXD010945 | Pride
Peptidylglycine -amidating monooxygenase Matrix metalloproteinase Cilia Carboxypeptidase Pherophorin Mating Prohormone convertase Subtilisin Signal peptide 
TranscriptomicsCocaine-regulated expression of striatal microRNAs
We cataloged miRNA expression in the nucleus accumbens and at striatal synapses in control and chronically cocaine-treated mice. We identified cocaine-responsive miRNAs, synaptically-enriched and depleted miRNA families, and confirmed cocaine-induced changes in protein expression for several predict...
ORGANISM(S): Mus musculus 
2011-05-13 | E-GEOD-29261 | biostudies-arrayexpress
TranscriptomicsEffects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome.
Genetic association studies, pharmacological investigations and analysis of mice-lacking individual genes have made it clear that Cocaine administration and Withdrawal have a profound impact on multiple neurotransmitter systems. The GABAergic medium spiny neurons of the nucleus accumbens (NAc) exhib...
ORGANISM(S): Mus musculus 
2013-01-10 | E-GEOD-43410 | biostudies-arrayexpress
TranscriptomicsSignaling from the secretory granule to the nucleus: Uhmk1 and PAM
Neurons and endocrine cells package peptides in secretory granules (large dense core vesicles; LDCVs) for storage and stimulated release. Studies of PAM, an essential secretory granule membrane enzyme, revealed a pathway that can relay information from secretory granules to the nucleus, resulting i...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-22509 | biostudies-arrayexpress
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