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Proteomicsβ-Adrenergic regulation of metabolism in macrophages
Macrophages have important roles in the immune system including clearing pathogens and wound healing. Metabolic phenotypes have been associated with functional phenotypes, where pro-inflammatory macrophages have an increased rate of glycolysis and anti-inflammatory macrophages primarily use oxidativ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD022670 | Pride
Lc-msms Macrophage Human 
ProteomicsGlobal protein analysis of pediatric acute leukemia patients and matched xenografts
Proteomics reveal protein stability after xenotransplantation in murine models. Tryptic peptide digests from patient mononuclear cells were analyzed by Data Independent Acquisition (DIA) mass spectrometry. High-pH fractionation was performed on a pool of samples, followed by data dependent acquisiti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-12-02 | MSV000084646 | MassIVE
ProteomicsN terminome analysis of pediatric acute leukemia patients and matched xenografts
Proteomics reveal PTM stability after xenotransplantation in murine models. N termini enriched using HUNTER technique were analyzed by Data Independent Acquisition (DIA) mass spectrometry. High-pH fractionation was performed on a pool of samples, followed by data dependent acquisition (DDA) mass spe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-12-02 | MSV000084643 | MassIVE
ProteomicsPhosphoproteome analysis of pediatric acute leukemia patients and matched xenografts
Proteomics reveal PTM stability after xenotransplantation in murine models. Phosphopeptides enriched using magnetic FeNTA beads were analyzed by Data Independent Acquisition (DIA) mass spectrometry. High-pH fractionation was performed on a pool of samples, followed by data dependent acquisition (DDA...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-12-02 | MSV000084645 | MassIVE
ProteomicsCell line xenograft experiment
Pediatric ALL cell line 380 was injected via tail vein into NSG mice. Triplicate 380 cell samples were also prepared at the timepoint of injection and stored at -80 oC for comparative analysis with CDXs. Mice were euthanized at onset of leukemia symptoms and spleen, bone marrow and liver samples wer...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-20 | MSV000086727 | MassIVE
GenomicsABO_OICR_DATASET - samples
OICR PANCREATIC CANCER DATASET
EGAD00001000262 | EGA
GenomicsABO_OICR_DATASET_2 - samples
OICR PANCREATIC CANCER DATASET 2
EGAD00001000276 | EGA
GenomicsICGC_PACA-AU_20160429 - samples
Additional sequencing data for 173 donors in EGAS00001000154, a study of Pancreatic Ductal Adenocarcinoma. WGS libraries were used for high-cellularity cases, WXS sequencing to high depth on low-cellularity cases. HiSeq 2xxx platform was used in all cases. The analysis files associated with this dat...
EGAD00001002192 | EGA
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
GenomicsGenome Landscape of Primary Pancreatic Ductal Adenocarcinoma
The purpose of the Australian ICGC Pancreatic Cancer Genome Sequencing Initiative study is to identify the common driving mutations underlying the initiation and development of Pancreatic Adenocarcinoma in a large cohort of pancreatic cancer patients (n=350). Matched genome sequences will be generat...
EGAS00001000154 | EGA
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