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Alternative polyadenylation (APA) has been implicated in a variety of developmental and disease processes, such as stem cell differentiation and cancer. A particularly dramatic form of APA has been documented in the developing nervous system of flies and mammals, whereby a variety of neurogenic gene...
ORGANISM(S): Drosophila melanogaster 
We investigated mRNA regulatory proteins of the ELAV family following 10 min global brain ischemia and 8 hrs reperfusion (8R) or non-ischemic controls (NIC) in rat hippocampal CA1 and CA3. There were three main experiments: (1) Shot-gun proteomics of polysome pellets from NIC and 8R CA1 and CA3, (2)...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-07-07 | PXD004078 | Pride
Three potential ELAV-like proteins of T. brucei, including Tb927.3.2930, Tb927.7.5380, and Tb927.8.6650, were either inhibited by RNAi or phenotypically activated by over-expression, followed by microarray analysis of the transcriptome. The results indicated that these ELAV-like proteins regulate th...
ORGANISM(S): Trypanosoma brucei 
ELAV mediates circular RNA biogenesis in neurons [RNA-Seq]
ELAV mediates circular RNA biogenesis in neurons [RIP-seq]
ELAV mediates circular RNA biogenesis in neurons [RNA-seq, S2]
ELAV mediates circular RNA biogenesis in neurons [RNA-seq, dm]
ELAV mediates circular RNA biogenesis in neurons [RNA-seq, RNaseR]
ELAV mediates circular RNA biogenesis in neurons [RNA-seq, sm]
A tagged ectopic version of the ELAV-like protein Tb927.8.6650 of T. brucei was expressed in stable cell lines and pulled down. Co-purifying transcripts were analyzed by sequencing to identify RNAs associated with Tb927.8.6650. Stable procyclic form cell lines expressing tetracycline-inducible TAP-t...
ORGANISM(S): Trypanosoma brucei 
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