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ProteomicsQUANTITATIVE PHOSPHOPROTEOMIC PROFILING OF PRIMARY RETINOBLASTOMA TUMORS
Retinoblastoma is a malignant tumor of the retina which most often occurs in children below 5 years of age with an incident rate of about 1 in 15,000 to 18,000 live births. Retinoblastoma is the first ever cancer that was reported to have a genetic basis. It occurs widely due to inactivating mutatio...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD007228 | Pride
Retinoblastoma Lc-ms Phosphoproteomics 
ProteomicsPreclinical targeted therapy for retinoblastoma using EpCAM Aptamer siRNA chimeras
siRNAs have played a major role in cancer drug discovery, but their potential is hampered due to off-target effects. Thus, delivery systems like RNA aptamers have been used to enhance the specific delivery of these siRNAs to cancer stem cells. We report the efficacy of three different EpCAM aptamer ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD008221 | Pride
Retinoblastoma Targeted delivery Cancer stem cells Epcam 
ProteomicsProteomic profiling of retinoblastoma by high resolution mass spectrometry
We performed a high throughput comparative proteomics study to identify differentially expressed proteins that could serve as putative targets in retinoblastoma. We used iTRAQ based quantitative proteomics approach and analyzed the samples on orbitrap velos mass spectrometer. We identified and quant...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD002774 | Pride
Quantitative proteomics Retina Cancer Mass spectrometry Retinoblastoma Itraq 
ProteomicsTCF4 trinucleotide repeat expansion drives distinct proteomic signatures in Fuchs endothelial corneal dystrophy
The aims of this study were to use an isogenic cell model system to investigate the proteomic consequences of TCF4 trinucleotide repeat expansion in Fuchs endothelial corneal dystrophy (FECD) and to identify potential molecular pathways contributing to disease pathogenesis. We used our previously es...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD075094 | Pride
Retina Fuchs endothelial corneal dystrophy (fecd) Ctg repeat 
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