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Study on changes in gene expression in primary cultures of neonatal rat ventricular cardiomyocytes to electric stimulation. Through comparing non-stimulated, stimulated and blebbistatin supplemented and stimulated cultures we set out to identify the genes that are specifically activated by electric ...
ORGANISM(S): Rattus norvegicus 
We performed transcutaneous electrode stimulation to the tibialis anterior (TA) muscle of rats to mimic resistance exercise and mass spectrometer to measure the changes in protein expression following exercise. Wistar male rats (11-week-old) reared at room temperature (21-25°C) on a 12:12 h light-da...
ORGANISM(S): Rattus Norvegicus 
We recently identified C18ORF25 as a new exercise-regulated phophoprotein. To investigate potential in vivo functions of C18ORF25, we used CRISPR/Cas9 to generate a whole-body knock-out (KO) mouse model on a C57BL/6J background. Proteomic analysis was performed to identify potental changes in the pr...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-18 | PXD031101 | Pride
This study investigates the role of peroxiredoxin 2 (PRDX2) in mediating oxidative adaptations in human skeletal muscle myotubes subjected to mechanical contraction and hydrogen peroxide (H2O2) exposure. additionally, the effect of an electrical stimulation protocol was assessed pre and post PRDX2 K...
ORGANISM(S): Homo sapiens 
Spinal cord injury (SCI) causes severe bone loss and disrupts connections between higher centers in the central nervous system (CNS) and bone. Muscle contraction elicited by functional electrical stimulation (FES) partially protects against loss of bone but cellular and molecular events by which th...
ORGANISM(S): Rattus norvegicus 
Purpose: The goal of this study was to determine the gene expression changes that occur over 7 days in parralyzed muscle in response to isometric contraction elicited by electrical stimulation initiated 4 months after spinal cord injury and to compare such changes to those observed in a normal muscl...
ORGANISM(S): Rattus norvegicus 
We hypothesized that muscle contraction produces a cellular stress signal capable to increase lipolysis to sustain fuel availability during exercise. The aim of the present study was to identify novel exercise-regulated myokines, aka exerkines, able to promote lipolysis in human adipocytes. To this ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD014126 | Pride
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