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MetabolomicsEMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress
The long-term maintenance of hematopoietic stem cells (HSCs) relies on the regulation of endoplasmic reticulum (ER) stress at a low level, but the underlying mechanism remains poorly understood. Here, we demonstrate that suppression of ER stress improves the functions of HSCs and protects HSCs again...
2025-06-04 | MTBLS12491 | MetaboLights
MetabolomicsEMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress
The long-term maintenance of hematopoietic stem cells (HSCs) relies on the regulation of endoplasmic reticulum (ER) stress at a low level, but the underlying mechanism remains poorly understood. Here, we demonstrate that suppression of ER stress improves the functions of HSCs and protects HSCs again...
2025-06-04 | MTBLS12489 | MetaboLights
ProteomicsEMP1 preserves hematopoietic stem cell potential under homeostasis and radiation-induced injury by alleviating ER stress
To illustrate EMP1-interacting proteins, we performed co-immunoprecipitation (co-IP) followed by mass spectrometry using HSPCs (Lin-c-Kit+) to characterize protein interactomes of EMP1. Murine HSPCs (Lin-c-Kit+) were infected with retrovirus to force EMP1 overexpression (with HA tag). Then IgG or HA...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-13 | PXD055884 | Pride
Hspcs Emp1 
GenomicsEMP1 preserves hematopoietic stem cell potential under homeostasis and radiation-induced injury by alleviating ER stress [EMP1 RNA-seq]
EMP1 preserves hematopoietic stem cell potential under homeostasis and radiation-induced injury by alleviating ER stress [EMP1 RNA-seq]
PRJNA1162435 | ENA
TranscriptomicsEMP1 preserves hematopoietic stem cell potential under homeostasis and radiation-induced injury by alleviating ER stress [EMP1 RNA-seq]
Hematopoietic stem cells (HSCs) play a crucial role in lifelong hematopoiesis by generating all blood lineages. The long-term maintenance of HSCs relies on the regulation of endoplasmic reticulum (ER) stress at a low level. However, the precise control of ER stress in HSCs remains largely unknown. I...
ORGANISM(S): Mus musculus 
2025-03-27 | GSE277442 | GEO
UnknownExpression of EMP1, EMP2, and EMP3 in breast phyllodes tumors.
Not available
S-EPMC7454950 | biostudies-literature
UnknownEMP1 as a Potential Biomarker in Liver Fibrosis: A Bioinformatics Analysis.
Not available
S-EPMC10060069 | biostudies-literature
GenomicsSingle-Cell Transcriptomic Profiling of Immune Cells from Parental and EMP1-Deficient MB49 Bladder Tumors.
Single-Cell Transcriptomic Profiling of Immune Cells from Parental and EMP1-Deficient MB49 Bladder Tumors.
PRJNA1514019 | ENA
Unknownp53, miR-34a and EMP1-Newly Identified Targets of TFF3 Signaling in Y79 Retinoblastoma Cells.
Not available
S-EPMC6747266 | biostudies-literature
UnknownEMP1 regulates cell proliferation, migration and invasion in triple negative breast cancer through PI3K-AKT signaling.
Not available
S-EPMC12738301 | biostudies-literature
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