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GenomicsMapping cells through time and space with moscot - pancreatic endocrinogenesis multiome
Mapping cells through time and space with moscot - pancreatic endocrinogenesis multiome
PRJNA1151677 | ENA
GenomicsComprehensive single-cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis
Comprehensive single-cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis
PRJNA546282 | ENA
TranscriptomicsDecoding pancreatic endocrine cell differentiation and beta-cell regeneration in zebrafish
The aim of the study is to investigate the endocrinogenesis process in zebrafish pancreas during normal development and regenerative condition.
ORGANISM(S): Danio rerio 
2023-03-14 | GSE226841 | GEO
GenomicsCharting endocrine progenitors across species and organs
Hormone-producing cells in the pancreas and intestine regulate whole-body metabolism and are key targets for causal therapies for diabetes and obesity. A deeper understanding of endocrine lineage formation (endocrinogenesis) in these organs is essential to elucidate disease mechanisms and develop im...
ORGANISM(S): Mus musculus 
2026-09-01 | GSE342091 | GEO
ProteomicsCharting endocrine progenitors across species and organs
Hormone-producing cells in the pancreas and intestine regulate whole-body metabolism and are key targets for causal therapies for diabetes and obesity. A deeper understanding of endocrine lineage formation (endocrinogenesis) in these organs is essential to elucidate disease mechanisms and develop im...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-25 | PXD076279 | Pride
Diabetes Ngn3 Pancreas Proteomics Endocrine progenitor Β-cells 
TranscriptomicsSequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans
The pancreatic islet contains multiple hormone+ endocrine lineages (alpha, beta, delta, PP and epsilon cells), but the developmental processes that underlie endocrinogenesis are poorly understood. Here, we generated novel mouse lines and combined them with various genetic tools to enrich all types o...
ORGANISM(S): Mus musculus 
2021-04-20 | GSE139627 | GEO
UnknownSequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans.
Not available
S-EPMC8324815 | biostudies-literature
UnknownSalt-inducible kinases transduce mechanical forces into the specification of the pancreatic endocrine lineage.
Not available
S-EPMC12069894 | biostudies-literature
TranscriptomicsMapping cells through time and space with moscot - pancreatic endocrinogenesis multiome
This dataset consists of single-nucleus RNA-seq and single-cell ATAC-seq (10X multiome) data from 3 embryonic stages (E14.5-16.5) of pancreatic epithelial cells from Neurogenin3 (Ngn3)-Venus fusion (NVF) homozygous mice. Endocrine progenitor cells (NVF+) were enriched by FACS cell sorting.
ORGANISM(S): Mus musculus 
2024-08-26 | GSE275562 | GEO
ProteomicsInsulin deficiency distorts human pancreatic endocrine cell composition during development
Objective: The developmental effects of mutations in genes associated with monogenic diabetes on human pancreas development is not well understood. More specifically, if insulin gene recessive mutations influence the human endocrine lineage segregation still needs to be investigated. Methods: W...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD045366 | Pride
Β cell Dia Monogenic diabetes Islet composition Insulin Ipsc differentiation Endocrinogenesis Lc-ms/ms 
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