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MetabolomicsPolystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism

Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, and placental tissue. Although some studies indicate that micropl...

2026-02-05 | MTBLS13850 | MetaboLights
TranscriptomicsGene expression in human endometrial cancer tissues and serous papillary endometrial cancer cell line, SPAC-1L, treated by STAT1-siRNA and/or IFN-gamma
Endometrial cancer is one of the most common gynecologic malignancies, and patients with high grade disease, especially serous papillary subtype (SPEC) are often related to the poor outcomes. Recent genome-wide analyses have revealed that SPEC exhibits gene expression profiles that are distinct from...
ORGANISM(S): Homo sapiens 
2014-03-20 | E-GEOD-56026 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human endometrial cancer cell line Ishikawa treated with BMP2
To elucidate the biological function of BMP2 in endometrial cancer cells, Ishikawa, a human endometrial cancer cell line, was stimulated with BMP2 for indicated hours.
ORGANISM(S): Homo sapiens 
2021-09-30 | E-MTAB-10275 | biostudies-arrayexpress
ProteomicsRole of prorenin receptor (P)RR in endometrial cancer cell growth
Endometrial cancer is the most commonly diagnosed gynecologic malignancy in women after breast, lung and colorectal cancer. Despite numerous scientific advances, the incidence and mortality rate of endometrial cancer is on the rise. Considerable research effort has therefore been placed on understan...
ORGANISM(S): Homo sapiens (Human) 
2022-04-23 | PXD023042 | Pride
Quantitative proteomics Endometrial epithelial cancer cell Cellular proliferation Tandem mass tags An3ca and hec-1a Atp6ap2 (p)rr Ishikawa Cellular viability 
TranscriptomicsTranscription profiling of human xenografts produced from an endometrial cell line treated with bevacizumab (Avastin)
Microarrays were used to determine the efficacy of bevacizumab (a monoclonal antibody against the vascular endothelial growth factor and its receptors.) on endometrial cancer cells. Endometrial cancer is the most frequent gynecologic cancer in women. Long term outcomes for patients with advanced sta...
ORGANISM(S): Homo sapiens 
2009-11-16 | E-GEOD-18195 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of patient-derived endometrial cancer organoids (Berg HF)
Patient-derived endometrial cancer organoids. The data was used to compare gene expression profile between organoids, and to explore whether an organoid-derived gene signature could predict disease outcomes in independent patient cohorts.
ORGANISM(S): Homo sapiens 
2021-07-16 | E-MTAB-10664 | biostudies-arrayexpress
TranscriptomicsExpression data from MTDH knockdown in the Hec50co endometrial cancer cell line
Understanding the molecular underpinnings of chemoresistance is vital to design therapies to restore chemosensitivity. In particular, metadherin (MTDH) has been demonstrated to have a critical role in chemoresistance. Over-expression of MTDH has recently been implicated in poor clinical outcome in b...
ORGANISM(S): Homo sapiens 
2010-12-17 | E-GEOD-26134 | biostudies-arrayexpress
TranscriptomicsPharmacological inhibition of 17β-hydroxysteroid dehydrogenase inhibits endometrial cancer growth in an orthotopic xenograft mouse model
Experimental design: Endometrial tumours were induced orthotopically (in one uterine horn) in 8-week-old female athymic nude mice (Crl:NU(NCr)-Foxn1nu), using an Ishikawa-derived cell line (clones Ishi-M3-HSDA, described in Konings et al 2018). This cell line maintains the characteristics of the par...
ORGANISM(S): Mus musculus 
2021-04-09 | E-MTAB-10338 | biostudies-arrayexpress
TranscriptomicsProgesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer: cell line data
Every year more than 42,000 women die of endometrial cancer, mainly due to recurrent or metastatic disease. The presence of tumor infiltrating lymphocytes (TILs) as well as progesterone receptor (PR) positivity has been correlated with improved prognosis. This study describes two mechanisms by which...
ORGANISM(S): Homo sapiens 
2012-01-26 | E-GEOD-29435 | biostudies-arrayexpress
TranscriptomicsRestoring miR-200c to aggressive endometrial cancer cell line
Using a mimic miR-200c was restored to an aggressive, Type 2 endometrial cancer cell line, Hec50 We sought to identify genes regulated by miR-200c in an aggressive cancer.
ORGANISM(S): Homo sapiens 
2010-11-17 | E-GEOD-25332 | biostudies-arrayexpress
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