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ProteomicsMare endometritis and endometrial fibrosis
Mare persistent post-breeding endometritis may lead to endometrosis, characterized by excessive fibrosis, which is a major cause of subfertility/infertility. The aim of this work was to compare the proteome of equine endometrium from categories IIA and IIB, with and without endometritis, to identify...
ORGANISM(S): Equus caballus (Horse) 
2026-09-28 | PXD070769 | Pride
Mare Endometrial proteome Endometrial fibrosis Endometritis 
TranscriptomicsTranscriptional profiling of healthy versus cystic fibrosis human endometrial organoids upon hormonal exposure
Female cystic fibrosis (CF) patients are confronted with fertility deficiency, experiencing difficulties in getting pregnant. Underlying reasons remain elusive. In particular, it has only poorly been studied whether the endometrium, the inner lining of the womb and crucial tissue for embryo implanta...
ORGANISM(S): Homo sapiens 
2025-04-08 | E-MTAB-14456 | biostudies-arrayexpress
ProteomicsProteomic profiling of tissue and plasma from mares with endometrial fibrosis
Endometrial fibrosis causes subfertility in mares, and is characterized by excessive deposition of extracellular matrix. It is diagnosed by a histopathologic evaluation of a biopsy, but the prognostic value of a single biopsy is limited, and a better understanding of the pathogenesis is needed. To g...
ORGANISM(S): Equus caballus (Horse) 
2026-01-19 | PXD056558 | Pride
Endometrial proteome Fibrotic endometrial degeneration Data independent acquisition mass spectrometry Equine Reproduction 
ProteomicsRole of prorenin receptor (P)RR in endometrial cancer cell growth
Endometrial cancer is the most commonly diagnosed gynecologic malignancy in women after breast, lung and colorectal cancer. Despite numerous scientific advances, the incidence and mortality rate of endometrial cancer is on the rise. Considerable research effort has therefore been placed on understan...
ORGANISM(S): Homo sapiens (Human) 
2022-04-23 | PXD023042 | Pride
Quantitative proteomics Endometrial epithelial cancer cell Cellular proliferation Tandem mass tags An3ca and hec-1a Atp6ap2 (p)rr Ishikawa Cellular viability 
TranscriptomicsSingle-cell transcriptomics of wild-type and cystic fibrosis (F508del/del) mouse uterus
Female cystic fibrosis (CF) patients are confronted with fertility deficiency, experiencing difficulties in getting pregnant. Previous findings using CF mouse models indicate that CF negatively impacts female fertility in mice as it does in humans. Underlying reasons remain elusive. In particular, i...
ORGANISM(S): Mus musculus 
2025-10-31 | E-MTAB-14455 | biostudies-arrayexpress
TranscriptomicsAltered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice.
Cystic fibrosis (CF) mouse models exhibit exocrine pancreatic function yet do not develop adipose stores to the levels of non-CF mice. CF mice homozygous for the Cftr mutation (F508del) at 3 weeks (post-weaning) and 6 weeks (young adult) of age had markedly less adipose tissue than non-CF mice. Both...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-33319 | biostudies-arrayexpress
ProteomicsBidirectional interaction between PGE₂-preconditioned mesenchymal stem cells and myofibroblasts mediates antifibrotic effects: A proteomic investigation into equine endometrial fibrosis reversal
Endometrosis is a prevalent fibrotic condition in mares that impairs reproductive efficiency by inducing transdifferentiation of endometrial stromal cells into myofibroblasts, leading to excessive ECM deposition. Methods: To elucidate the molecular mechanisms underlying fibrosis resolution, this stu...
ORGANISM(S): Equus caballus (Horse) 
2025-09-29 | PXD067551 | Pride
Endometrosis  equine mesenshymal stem cells  mare endometrial  precondition with pge2  silac  myofibloblasts - equine mesenshymal stem cells interaction 
UnknownTargeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH.
Not available
S-EPMC10344943 | biostudies-literature
UnknownEndothelial senescence induced by PAI-1 promotes endometrial fibrosis.
Not available
S-EPMC11885584 | biostudies-literature
TranscriptomicsJnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis
Hepatic fibrosis is a wound-healing response to chronic liver injury, which may result in cirrhosis and liver failure. The c-Jun N-terminal kinase-1 (JNK1) gene has been shown to be involved in liver fibrosis. Here, we aimed to investigate the molecular mechanism and identify the cell-type involved ...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-40041 | biostudies-arrayexpress
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