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ProteomicsProximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
Membrane contact sites between organelles are critical for transfer of biomolecules. Lipid droplets store fatty acids and form contacts with mitochondria, which regulate fatty acid oxidation and adenosine triphosphate production. Protein compartmentalization at lipid droplet-mitochondria contact sit...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD060912 | Pride
Lipid droplet Fatty acid Lipid metabolism Lipidomics Lipotoxicity Mitochondria Cell metabolism 
ProteomicsBRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III
Inter-organellar communication is critical for cellular metabolic homeostasis. One of the most abundant inter-organellar interactions are those at the endoplasmic reticulum and mitochondria contact sites (ERMCS). However, a detailed understanding of the mechanisms governing ERMCS regulation and thei...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD056917 | Pride
Endoplasmic reticulum-mitochondria contact sites Bromodomain protein Mitochondrial electron transport chain. High-throughput screening 
UnknownChemical Modulation of Mitochondria-Endoplasmic Reticulum Contact Sites.
Not available
S-EPMC7408517 | biostudies-literature
ProteomicsIdentification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites
Membrane contact sites are cellular structures that mediate inter-organelle exchange and communication. The endoplasmic reticulum (ER), which forms a network extending throughout the cytoplasm, possesses two known major tether proteins, named VAP-A and VAP-B, that allow its interaction with other or...
ORGANISM(S): Homo sapiens (Human) 
2018-06-05 | PXD009575 | Pride
Endoplasmic reticulum Mospd2 Ffat motif 
UnknownContact sites between endoplasmic reticulum sheets and mitochondria regulate mitochondrial DNA replication and segregation.
Not available
S-EPMC10391914 | biostudies-literature
UnknownMiga-mediated endoplasmic reticulum-mitochondria contact sites regulate neuronal homeostasis.
Not available
S-EPMC7556861 | biostudies-literature
UnknownKey genes expressed in mitochondria‑endoplasmic reticulum contact sites in cancer (Review).
Not available
S-EPMC10018458 | biostudies-literature
ProteomicsDengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis
With no therapeutics available, there is an urgent need to better understand the pathogenesis of (ortho)flaviviruses which constitute a threat to public health worldwide. During infection, dengue virus (DENV) and Zika virus (ZIKV), two flavivirusesinduce alterations of mitochondria morphology to fav...
ORGANISM(S): Homo sapiens (Human) Dengue virus 
2024-12-20 | PXD057947 | Pride
Dengue virus (denv) Contact sites Viral infection Respiration Mitochondria Apoptosis Zika virus (zikv) 
ProteomicsContact-ID, a new tool for profiling organelle-membrane contact sites, reveals regulatory proteins of mitochondrial-associated membrane formation
The mitochondria-associated membrane (MAM) has emerged as a cellular signaling hub regulating various cellular processes. However, its molecular components remain unclear owing to lack of reliable methods to purify the intact MAM proteome in a physiological context. Here, we introduce Contact-ID, a ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084362 | MassIVE
ProteomicsINTERACTOME ANALYSIS IDENTIFIES THE ROLE OF BZW2 IN PROMOTING ENDOPLASMIC RETICULUM-MITOCHONDRIAL CONTACT AND MITOCHONDRIAL METABOLISM
Maio et. al. presents a comprehensive and quantitative interactome of BZW2, a protein found to promote human cancers with little known about its molecular function. Many of the proteins identified were either mitochondrial or endoplasmic reticulum (ER) proteins, suggesting BZW2 may play a role in mi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD041354 | Pride
Mercs Lipid metabolism. Mitochondrial metabolism Mam Calcium Bzw2 Interactome 
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