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MetabolomicsA microfluidic chip recapitulating the human neurovascular unit with a functional blood-brain barrier for modeling gut-brain interactions

The blood-brain barrier (BBB) is essential for central nervous system homeostasis, but most current in vitro models lack structural and functional fidelity. We developed a physiologically relevant human neurovascular unit microfluidic chip (hNVU-on-a-chip) incorporating brain microvascular endoth...

2025-10-28 | MTBLS13230 | MetaboLights
ProteomicsBrain microvascular endothelial cells: INSR KD
The insulin receptor (INSR) mediates insulin signaling to modulate cellular functions. Although INSR is expressed at the blood-brain barrier (BBB), its role in the modulation of BBB function is poorly understood. Therefore, in this study, we aimed to analyze the effect of INSR knockdown on the expre...
ORGANISM(S): Homo Sapiens (human) 
2021-12-25 | PXD027326 | JPOST Repository
TranscriptomicsCulture induced changes in Blood-Brain Barrier transcriptome: implications for amino acid transporters in vivo
Tight homeostatic control of brain amino acids (AA) depends on transport via solute family carrier proteins expressed by the Blood-Brain Barrier (BBB) microvascular endothelial cells (BMEC). To characterize the mouse BMEC transcriptome and probe culture-induced changes microarray analyses of PECAM-1...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-14375 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of human iPSC-derived brain microvascular endothelial cells.
Induced pluripotent stem cells were differentiated to brain microvascular endothelial cells (BMECs) using previously published protocols with minor changes. RNA was collected from purified BMECs after barrier induction and submitted for sequencing.
ORGANISM(S): Homo sapiens 
2020-12-31 | E-MTAB-8802 | biostudies-arrayexpress
MetabolomicsLimosilactobacillus reuteri with indole-3-lactic acid-producing capacity protects against atherosclerosis by fortifying the gut-vascular barrier

Introduction: The gut microbiota and its metabolites are implicated in atherosclerosis, but the specific effector molecules and their pathophysiological significance remain unclear.

Objectives: This study aimed to identify key atheroprotective microbial metabolites and to elucidate the mech...

2026-01-31 | MTBLS13620 | MetaboLights
ProteomicsFasting upregulates the monocarboxylate transporter Mct1 at the rat blood-brain barrier through Ppar d activation
Fasting is increasingly recognized as a potential therapeutic intervention in the field of neurology and psychiatry. However, its impact upon the blood-brain barrier (BBB), which strictly regulates the cerebral uptake of a wide range of endogenous compounds and drugs, is unknown. In this study we us...
ORGANISM(S): Cellular Organisms 
2024-08-15 | PXD044587 | JPOST Repository
TranscriptomicsTranscriptome analysis of 3D model of blood-brain barrier exposed to West Nile virus (WNV)
Using RNA sequencing to map differentially expressed genes in the 3D model of the blood-brain barrier ( composed of human brain endothelial cells, human astrocytes, and human pericytes) challenged with WNV.
ORGANISM(S): Homo sapiens 
2021-01-01 | E-MTAB-9754 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of 3D model of blood-brain barrier exposed to Borrelia garini
Using RNA sequencing to map differentially expressed genes in the 3D model of the blood-brain barrier ( composed of human brain endothelial cells, human astrocytes, and human pericytes) challenged with Borrelia garini .
ORGANISM(S): Homo sapiens 
2021-01-01 | E-MTAB-9753 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of 3D model of blood-brain barrier exposed to tick-borne encephalitis virus (TBEV)
Using RNA sequencing to map differentially expressed genes in the 3D model of the blood-brain barrier ( composed of human brain endothelial cells, human astrocytes, and human pericytes) challenged with TBEV.
ORGANISM(S): Homo sapiens 
2021-01-01 | E-MTAB-9755 | biostudies-arrayexpress
ProteomicsMBEC4 cells with low-Arginine conditions
Amino acid transporters are expressed in the brain capillary endothelial cells, which form the blood-brain barrier, and their expression levels change during the neonatal period. This study aimed to investigate the molecular mechanisms regulating the amino acid transporter levels in mouse brain capi...
ORGANISM(S): Mus Musculus (mouse) 
2025-04-11 | PXD054477 | JPOST Repository
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