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The circulating proteome offers insight into the stage and severity of the immune response. To characterise the release kinetics and cellular source of plasma protein changes, serial samples were obtained from healthy volunteers (n=10, 3 time-points) injected with low-dose endotoxin (LPS) and analys...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-11 | PXD021077 | Pride
IL-6 induces IL4ralpha expression in macrophages. This mechanism is necessary to promote macrophage polarization towards an M2-phenotype and is crucial to limit the inflammatory response both upon obesity and LPS-endotoxemia. In this dataset, we include the expression data obtained from primary muri...
ORGANISM(S): Mus musculus 
Inappropriate or sustained activation of innate immunity is a pathologic feature of several common cardio-metabolic disorders. Little is known, however, about transcriptomic modulation during inflammatory stress in disease-relevant human tissues. We applied deep RNA sequencing (RNA-seq) during low-d...
ORGANISM(S): Homo sapiens 
The Wnt pathway inhibitor, LGK974 has suppressive effects for LPS-induced endotoxemia
Single-cell RNA sequencing of liver parenchymal cells from murine model of endotoxemia
Single-cell RNA sequencing of liver nonparenchymal cells from murine model of endotoxemia
FABP7 expression modulates the response of astrocyte to induced endotoxemia.
Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia
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