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MetabolomicsGut Microbiota-Mediated Conversion of Coenzyme A in Vitro

The bacterium Roseburia inulinivorans harbors enzymes predicted to be involved in coenzyme A (CoA) metabolism. To experimentally validate the source of pantetheine, we performed an in vitro co-culture of R. inulinivorans with CoA and analyzed metabolomic profiles. The results demonstrated a signi...

2025-10-15 | MTBLS13143 | MetaboLights
MetabolomicsMetabolome analysis reveal key regulatory pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense

A total of 445 and 247 differently expressed metabolites (DEMs) were identified in the hepatopancreas and muscle. In addition, 11 KEGG pathways, which mainly include lysine biosynthesis, lysine degradation, aminoacyl-tRNA biosynthesis and purine metabolism, were sign...

2023-02-28 | MTBLS6663 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_lipid

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12741 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_untargeted metabolites_flux_FAO

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12738 | MetaboLights
MetabolomicsMultiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease
We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were foun...
2025-04-25 | MTBLS4332 | MetaboLights
MetabolomicsMetabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in...
2019-09-06 | MTBLS598 | MetaboLights
ProteomicsCemR atypical response regulator impacts energy conversion in Campylobacteria
Campylobacter jejuni and Arcobacter butzleri are microaerobic food-borne human gastrointestinal pathogens that mainly cause diarrheal disease. These related species of the Campylobacteria class face variable atmospheric environments during infection and transmission, ranging from nearly anaerobic to...
ORGANISM(S): Aliarcobacter butzleri RM4018 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Bacteria 
2024-06-14 | PXD048711 | Pride
Metabolism Arcobacter butzleri Abu0127 Cj1608 Campylobacter jejuni Energy conversion Regulation 
UnknownEnergy comparison of sequential and integrated CO2 capture and electrochemical conversion.
Not available
S-EPMC9474516 | biostudies-literature
ProteomicsGlobal lysine acetylation and 2-hydroxyisobutyrylation reveal the metabolism conversion mechanism in Giardia lamblia
Giardia lamblia (G. lamblia) disease is a zoonosis with a-infection rate affecting the general population of the world. Despite the constant possibility of damage due to their own metabolism, G. lamblia have survived and evolved to adapt to various environments. However, research on energy-metabolis...
ORGANISM(S): Giardia lamblia P15 
2021-01-04 | PXD022317 | Pride
Giardia lamblia  acetylation  2-hydroxyisobutyrylation  metabolism conversion. 
UnknownCell wall targeted in planta iron accumulation enhances biomass conversion and seed iron concentration in Arabidopsis and rice.
Not available
S-EPMC5043494 | biostudies-literature
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