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UnknownRetroviral integrase protein and intasome nucleoprotein complex structures.
Not available
S-EPMC5329712 | biostudies-literature
TranscriptomicsStructural basis for retroviral integration into nucleosomes
Retroviral integration is catalyzed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foamy vi...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-67730 | biostudies-arrayexpress
TranscriptomicsSequencing of reaction products from protospacer integration by Cas1-Cas2
We report the sites of protospacer integration into plasmids by Cas1-Cas2. The goal of this study is to determine the role of sequence elements on protospacer integration. Methods: Cas1-Cas2 integration products were fragmented, end-repaired, adapter ligated, PCR amplified, and analyzed by Illumina ...
ORGANISM(S): Cloning vector pUC19 
2015-01-30 | E-GEOD-64552 | biostudies-arrayexpress
ProteomicsPhosphorylation of CPSF6 RS-like domain
Cleavage factor I mammalian (CFIm) complex, composed of cleavage and polyadenylation specificity factor CPSF6, regulates alternative polyadenylation (APA). CPSF6 has a RS-like domain which plays role in protein -protein interactions. This interaction might have role in alternative polyadenylation s...
ORGANISM(S): Homo sapiens (Human) 
2019-04-01 | PXD012713 | Pride
Cfim68 Cpsf6 Rs domain Rs-like domain Apa 
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