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ProteomicsPhosphorylation of CPSF6 RS-like domain
Cleavage factor I mammalian (CFIm) complex, composed of cleavage and polyadenylation specificity factor CPSF6, regulates alternative polyadenylation (APA). CPSF6 has a RS-like domain which plays role in protein -protein interactions. This interaction might have role in alternative polyadenylation s...
ORGANISM(S): Homo sapiens (Human) 
2019-04-01 | PXD012713 | Pride
Cfim68 Cpsf6 Rs domain Rs-like domain Apa 
TranscriptomicsThe transcriptome-wide CPSF6-induced APA alterations in HCC cells
In this study, we showed that CPSF6 promoted HCC cell growth, migration and metastasis in vitro and in vivo. In order to understand the underlying mechanisms of CPSF6, we aimed to perform a APA profiling analysis in hepatocyte and hepatoma carcinoma cells under different CPSF6 expression conditions ...
ORGANISM(S): Homo sapiens 
2021-04-01 | E-MTAB-9458 | biostudies-arrayexpress
TranscriptomicsThe transcriptome-wide CPSF6-induced APA alterations in gastric cancer cells
In this study, we showed that knockdown of CPSF6 inhibited GC cell growth and promoted apoptosis in vitro and in vivo. In order to understand the underlying mechanisms of CPSF6, we performed an APA profiling analysis in wild-type and CPSF6-knockdown AGS cells, using 3T-seq method.
ORGANISM(S): Homo sapiens 
2021-07-31 | E-MTAB-9980 | biostudies-arrayexpress
ProteomicsPrion-like low complexity regions enable avid virus-host interactions during HIV-1 infection
Cellular proteins CPSF6, NUP153 and SEC24C play crucial roles in HIV-1 infection. While weak interactions of short FG peptides to isolated capsid hexamers have been characterized, how these proteins engage biologically relevant extended HIV-1 capsid lattices is unknown. We have identified that prion...
ORGANISM(S): Homo sapiens (Human) Human immunodeficiency virus 
2022-08-31 | PXD030332 | Pride
Hdx-ms Cpsf6 Hiv-1 
GenomicsThe transcriptome-wide CPSF6-induced APA alterations in HCC cells
The transcriptome-wide CPSF6-induced APA alterations in HCC cells
PRJEB40139 | ENA
GenomicsThe gene expression profiles of leukemia cells isolated from spleens of CreMx-1 CPSF6-RARG mice and Wt1F/+CreMx-1 CPSF6-RARG mice
The gene expression profiles of leukemia cells isolated from spleens of CreMx-1 CPSF6-RARG mice and Wt1F/+CreMx-1 CPSF6-RARG mice
PRJNA1018457 | ENA
GenomicsThe transcriptome-wide CPSF6-induced APA alterations in gastric cancer cells
The transcriptome-wide CPSF6-induced APA alterations in gastric cancer cells
PRJEB42340 | ENA
UnknownCPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target: Role of CPSF6 in Breast Cancer.
Not available
S-EPMC5514498 | biostudies-literature
GenomicsCPSF6 regulates alternative polydenylation and proliferation of cancer cell through phase separation Ⅱ
CPSF6 regulates alternative polydenylation and proliferation of cancer cell through phase separation Ⅱ
PRJNA962595 | ENA
TranscriptomicsCPSF6 regulates alternative polydenylation and proliferation of cancer cell through phase separation Ⅱ
To verify the effect of phosphorylation of CPSF6 by CLK2 on APA, we co overexpressed CLK2 and wild-type CPSF6 or phosphorylated mutant CPSF6 in HEK293T cells
ORGANISM(S): Homo sapiens 
2024-08-15 | GSE230813 | GEO
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