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TranscriptomicsDissecting engineered cell types and enhancing cell fate conversion via CellNet
Engineering clinically relevant cells in vitro holds promise for regenerative medicine, but most protocols fail to faithfully recapitulate target cell properties. To address this, we developed CellNet, a network biology platform that determines whether engineered cells are equivalent to their target...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-59037 | biostudies-arrayexpress
GenomicsEngineered cell entry links receptor biology with single-cell genomics
Engineered cell entry links receptor biology with single-cell genomics
PRJNA878699 | ENA
ProteomicsProteomic comparison of tissue engineered tendon constructs derived young and old cells
Tendon injuries can occur due to sports related incidents, as a result of trauma to overuse or during disease or ageing. Tissue engineering can offer great potential in the treatment of a tendon injury. The preferred cell source is autologous in order to reduce immune response in the treated individ...
ORGANISM(S): Equus caballus (Horse) 
2018-10-26 | PXD005322 | Pride
Tendon Tissue engineered constructs Young and old Lc-ms/ms 
GenomicsEngineered cell entry links receptor biology with single-cell genomics [scRNA-Seq]
Engineered cell entry links receptor biology with single-cell genomics [scRNA-Seq]
PRJNA878700 | ENA
ProteomicsComprehensive proteomic comparison between native tendon and ligament and 3D tissue engineered tendon and ligament constructs
Tendons and ligaments are important biological structures in both humans and animals. They are part of dense connective tissue and are crucial to the functioning of the musculoskeletal system. However, they are commonly damaged due to age-related wear and tear, trauma or sports related incidents, wh...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2016-06-27 | PXD003094 | Pride
3d tissue engineered ligament Native tendon Native ligament 3d tissue engineered tendon 
GenomicsEngineered cell entry links receptor biology with single-cell genomics [bulk RNA-Seq]
Engineered cell entry links receptor biology with single-cell genomics [bulk RNA-Seq]
PRJNA878678 | ENA
GenomicsEngineered receptors for human cytomegalovirus that are orthogonal to normal human biology
Engineered receptors for human cytomegalovirus that are orthogonal to normal human biology
PRJNA574965 | ENA
UnknownGenetically engineered mouse models for studying radiation biology.
Not available
S-EPMC6363345 | biostudies-literature
TranscriptomicsTranscriptional reprogramming of engineered cellobiose-utilizing Saccharomyces cerevisiae in response to cellobiose revealed by RNA-Seq
Saccharomyces cerevisiae cannot metabolize cellobiose in nature. Here, S. cerevisiae was engineered to achieve cellobiose utilization by introducing both a cellodextrin transporter gene (cdt-1) and an intracellular β-glucosidase gene (gh1-1) from Neurospora crassa. We sequenced mRNA from anaerobic e...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-10 | E-GEOD-54825 | biostudies-arrayexpress
ProteomicsMetabolic modulation of tumors with engineered bacteria for immunotherapy
The availability of L-arginine in tumors is a key determinant of an efficient anti-tumor T cell response. Consequently, elevation of typically low L-arginine levels within the tumor may greatly potentiate the anti-tumor responses of immune checkpoint inhibitors, such as PD-L1 blocking antibodies. H...
ORGANISM(S): Escherichia coli 
2021-07-13 | PXD027167 | Pride
Cancer immunotherapy L-arginine Synthetic biology Metabolic modulation of tumors Bacteria-based therapies 
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