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MetabolomicsProteomic and metabolomic profiling of extracellular vesicles produced by human gut archaea

Gastrointestinal bacteria interact with the host and each other through various mechanisms, including the production of extracellular vesicles (EVs). However, the composition and potential roles of EVs released by gut archaea are poorly understood. Here, we study EVs produced by four strains of h...

2025-07-01 | MTBLS12422 | MetaboLights
MetabolomicsPrevention of acute graft-versus-host disease via single-dose administration of bioengineered extracellular vesicles
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for various hematological and immunologic diseases, but acute graft-versus-host disease (aGVHD) remains a major cause of morbidity and mortality. We previously discovered in patients and murine models that higher le...
2026-09-11 | MTBLS15633 | MetaboLights
UnknownQuantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution.
Not available
S-EPMC8329990 | biostudies-literature
ProteomicsEngineered MSC-derived extracellular vesicles maintain proteomic characteristics comparable with naïve MSC-derived extracellular vesicles
Extracellular vesicles reflect the contents and characteristics of their donor cells. When donor cells were engineered to express specific protein, their characteristic may change, potentially altering the composition of EVs. This study aims to evaluate the degree of similarity in protein contents b...
ORGANISM(S): Homo sapiens (Human) 
2025-01-31 | PXD060047 | Pride
Human Lc-msms Extracellular vesicle Mesenchymal stem cell Engineered extracellular vesicle 
UnknownEngineered Extracellular Vesicle-Based Therapies for Valvular Heart Disease.
Not available
S-EPMC10550890 | biostudies-literature
ProteomicsCirculating ACE2-expressing Extracellular Vesicles as an Innate Antiviral Response and A Decoy Therapy to Block Broad Strains of SARS-CoV-2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)has caused the pandemic of the coronavirus induced disease 2019 (COVID-19) with 216 million cases and 4.5 million deathsas of September 2021.Thathas been exacerbated by mutated variants such as α, β, and with high infection rates and i...
ORGANISM(S): Homo Sapiens (human) 
2021-12-10 | PXD029662 | JPOST Repository
GenomicsExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
PRJNA713983 | ENA
UnknownDendritic cell progenitors engineered to express extracellular-vesicle-internalizing receptors enhance cancer immunotherapy in mouse models.
Not available
S-EPMC12528441 | biostudies-literature
UnknownHaloTag display enables quantitative single-particle characterisation and functionalisation of engineered extracellular vesicles.
Not available
S-EPMC11224594 | biostudies-literature
ProteomicsIntradermal Delivery of Catalase via Extracellular Vesicles for Targeted Photoaging Therapy
We engineered a 313-cell line to produce EVs that were subsequently loaded with catalase (CAT), a key antioxidant enzyme. These CAT-loaded EVs (313EVs) exhibited high loading efficiency and maintained both vesicle integrity and enzymatic activity
ORGANISM(S): Rattus Norvegicus 
2025-12-12 | PXD072392 |
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