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MetabolomicsMetabolomic Analysis Reveals an Important Role of Sphingosine 1-phosphate in the Development of HFMD due to EV-A71 Infection

Hand, foot, and mouth disease (HFMD) is a serious pediatric infectious disease that causes immeasurable physical and mental health burdens. Currently, there is a lack of information on the mechanisms of HFMD severity and early diagnosis. We performed metabolomic profiling of sera from 84 Enterovi...

2024-11-14 | MTBLS11656 | MetaboLights
ProteomicsRole of Rab11 in Enterovirus A71 (EV-A71) infection
A siRNA screening using a commercially available membrane trafficking library identified Rab11 as a pro-viral host factor in motor neuron NSC34 cell line infected with EV-A71, a major causative agent of Hand, Foot and Mouth Disease (HFMD). This project aims at deciphering the role of Rab11 during EV...
ORGANISM(S): Homo sapiens (Human) Enterovirus A71 
2024-06-28 | PXD043870 | Pride
Hfmd Enterovirus a71 (ev-a71) Rab11 
TranscriptomicsTranscriptomic Analysis Initially Reveals Monocyte/Macrophage Activation Drives EV-A71-Induced Immune Dysregulation and Neural Injury in Severe HFMD
Objective Enterovirus 71 (EV-A71) is a major pathogen of severe hand, foot and mouth disease (HFMD) in children, but the mechanism by which it develops into severe HFMD remains unclear, especially the role of macrophage-mediated immune dysregulation. Methods Macrophages infected with EV-A71 were col...
ORGANISM(S): Enterovirus A71 
2025-09-10 | GSE304239 | GEO
ProteomicsRNP remodeling during RNA virus replication through phosphoregulation of SR proteins revealed by metabolic labeling
Mechanisms used by positive-stranded RNA viruses to control the translation-replication switch remain largely unexplored. Using metabolic labeling coupled with quantitative proteomics analyses, we unraveled the protein composition of temporal ribonucleoprotein complexes (RNPs) isolated during early ...
ORGANISM(S): Homo sapiens (Human) Enterovirus A71 
2025-06-04 | PXD036890 | Pride
4su labeling Ev-a71 Ribonucleotide protein Sr protein 
GenomicsTranscriptomic Analysis Initially Reveals Monocyte/Macrophage Activation Drives EV-A71-Induced Immune Dysregulation and Neural Injury in Severe HFMD
Transcriptomic Analysis Initially Reveals Monocyte/Macrophage Activation Drives EV-A71-Induced Immune Dysregulation and Neural Injury in Severe HFMD
PRJNA1299456 | ENA
GenomicsEnterovirus A71 isolate:Human (infant) Stool
Enterovirus A71 isolate:Human (infant) Stool Genome sequencing
PRJNA647631 | ENA
UnknownFunctional Insights into Silymarin as an Antiviral Agent against Enterovirus A71 (EV-A71).
Not available
S-EPMC8395941 | biostudies-literature
UnknownInteraction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection.
Not available
S-EPMC7232526 | biostudies-literature
GenomicsEV-A71 qRT-PCR
Development of a new internally controlled one-step real-time RT-PCR for the molecular detection of enterovirus A71 in Africa and Madagascar.
PRJEB38355 | ENA
UnknownFlavonoids as Antiviral Agents for Enterovirus A71 (EV-A71).
Not available
S-EPMC7077323 | biostudies-literature
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