Enzymatic targets

Show results for

Unknown (1626)
Genomics (251)
Proteomics (250)
Transcriptomics (199)
Other (18)
Models (11)
Metabolomics (9)
Methylation profiling (8)
Genomic (2)
Multiomics (1)

Organisms

Homo sapiens (148)
Mus musculus (82)
Drosophila melanogaster (14)
Saccharomyces cerevisiae (8)
Rattus norvegicus (7)
Trypanosoma brucei (6)
Arabidopsis thaliana (4)
Plasmodium falciparum (3)
Bos taurus (3)
Escherichia coli (3)
Bombyx mori (2)
Enterococcus faecium (2)
Canis lupus familiaris (2)
Chlamydomonas reinhardtii (2)
Schizosaccharomyces pombe (2)
Mycobacterium tuberculosis (2)
Caenorhabditis elegans (2)
Corynebacterium glutamicum ATCC 13032 (2)
Escherichia coli str. K-12 substr. MG1655 (2)
Batrachochytrium dendrobatidis JAM81 (1)
Drosophila simulans (1)
Apis mellifera (1)
Staphylococcus aureus (1)
Sus scrofa (1)
Tachysurus vachellii (1)
Olea europaea (1)
Pyrodictium abyssi (1)
Methanosarcina mazei (1)
Methanobrevibacter smithii (1)
Methanomassiliicoccus luminyensis (1)

Organisms

Homo sapiens (73)
Mus musculus (61)
Drosophila melanogaster (9)
Saccharomyces cerevisiae (4)
Arabidopsis thaliana (3)
Bos taurus (3)
Trichoderma harzianum IOC 3844 (1)
Tachysurus vachellii (1)
Trichophyton rubrum (1)
Escherichia coli str. K-12 substr. MG1655 (1)
Chlamydomonas reinhardtii (1)
Corynebacterium glutamicum ATCC 13032 (1)
Schizosaccharomyces pombe (1)
Olea europaea (1)
Lactiplantibacillus plantarum (1)
Caenorhabditis elegans (1)
Malus domestica (1)
Solanum lycopersicum (1)
Oryza sativa (1)
Mycobacterium tuberculosis (1)
Rattus norvegicus (1)
Plasmodium falciparum (1)

Repository

pride (208)
ENA (192)
biostudies-arrayexpress (154)
geo (132)
MassIVE (18)
BioModels (11)
iProX (9)
jPOST (6)
MetaboLights (6)
PAXDB (6)
GNPS (3)
dbGaP (2)
PanoramaPublic (1)

Tissue

Cell culture (50)
Epithelial cell (19)
Brain (14)
Blood plasma (10)
Lung (10)
Kidney (9)
Heart (7)
Liver (7)
Skin (6)
Testis (5)
Whole body (5)
Permanent cell line cell (5)
Colon (5)
Bone marrow (4)
Macrophage (4)
Spleen (4)
Malignant cell (3)
Stomach (3)
Pancreas (3)
Cerebellum (3)
Lymph node (3)
Plant cell (3)
HeLa cell (3)
Leaf (3)
Glioblastoma multiforme cancer stem cell (2)
Myeloid suppressor cell (2)
Tongue (2)
Mammary gland epithelial cell (2)
Aorta (2)
Fungal cell (2)

Disease

Breast cancer (7)
Alzheimer's disease (4)
Colon cancer (4)
IDH-wildtype glioblastoma (3)
Brain glioblastoma multiforme (3)
Prostate adenocarcinoma (3)
Cervix carcinoma (3)
Melanoma (3)
Cardiovascular system disease (3)
Brain cancer (3)
Glioblastoma (3)
Disease free (3)
Skin melanoma (2)
Paracoccidioidomycosis (2)
Lung cancer (2)
Type 2 diabetes mellitus (2)
Glioblastoma classical subtype (1)
Alcohol dependence (1)
Diaphragm disease (1)
Pancreatic ductal carcinoma (1)
Allergic asthma (1)
Stomach cancer (1)
Cutaneous malignant melanoma 1 (1)
Lung carcinoma (1)
Skin cancer (1)
Hepatocellular carcinoma (1)
Non-small cell lung carcinoma (1)
Prostate cancer (1)
Lymphoma (1)
Cancer (1)

Technology Type

Mass Spectrometry (208)
Shotgun proteomics (106)
Bottom-up proteomics (42)
Data-dependent acquisition (28)
Affinity purification coupled with mass spectrometry proteomics (27)
Gel-based experiment (17)
Data-independent acquisition (16)
Top-down proteomics (6)
Chemical cross-linking coupled with mass spectrometry proteomics (6)
SRM/MRM (4)
Mass spectrometry assay (3)
Mass spectrometry (3)
Proteogenomics (2)
All-ion fragmentation (2)
SWATH MS (2)
Metaproteomics (1)
Mass spectrometry imaging (1)
RNA mass spectrometry (1)
MSE (1)
DiaPASEF (1)

Instrument Platform

LTQ Orbitrap Velos (3)
Illumina HiSeq 2500 (2)
Illumina NovaSeq 6000 (2)
NextSeq 500 (2)
SolariX (2)
Thermo Scientific LTQ FT Ultra (2)
Orbitrap Exploris 120 (2)
Q Exactive (2)
Liquid Chromatography MS - positive - reverse-phase (2)
Liquid Chromatography MS - negative - reverse-phase (2)
NextSeq 550 (1)
Illumina HiSeq 4000 (1)
Exactive Plus Orbitrap (Thermo Scientific) (1)
Orbitrap Exploris (1)
Orbitrap Q Exactive (1)
Impact II (1)
TripleTOF 5600 (1)
LTQ Orbitrap XL (1)
Orbitrap Eclipse (1)
Q Exactive HF (1)
TimsTOF Pro (1)
Q Exactive Plus (1)
Orbitrap Exploris 480 (1)
Q Exactive HF-X (1)
Orbitrap Fusion Lumos (1)
Pegasus 4D (1)
TSQ Vantage (Thermo Scientific) (1)
Liquid Chromatography MS - alternating - reverse phase (1)
Liquid Chromatography MS - positive - hilic (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2026 (57)
2025 (56)
2022 (45)
2024 (43)
2023 (41)
2021 (29)
2014 (29)
2016 (27)
2013 (27)
2020 (26)
2019 (26)
2012 (25)
2015 (23)
2018 (22)
2010 (20)
2011 (19)
2017 (16)
2009 (7)
2005 (4)
2008 (4)

UNIPROT ID/AC

C6THA9_SOYBN (6)
3847.GLYMA13G24180.1 (6)
A0A368UH97_SOYBN (6)
C6SXY3_SOYBN (6)
I1JFB7_SOYBN (6)
I1M8E3_SOYBN (6)
C6TFP4_SOYBN (6)
K7L8R0_SOYBN (6)
A0A0R0GHB3_SOYBN (6)
I1K8X7_SOYBN (6)
A0A0R0IVG1_SOYBN (6)
I1JR38_SOYBN (6)
I1KM26_SOYBN (6)
A0A368UI56_SOYBN (6)
A0A0R0F023_SOYBN (6)
I1M4U9_SOYBN (6)
I1J7I5_SOYBN (6)
K7MQM3_SOYBN (6)
A0A0R0K474_SOYBN (6)
K7LW98_SOYBN (6)
I1M5X1_SOYBN (6)
K7MFX1_SOYBN (6)
A0A368UGN4_SOYBN (6)
K7LM62_SOYBN (6)
A0A0R0EUL8_SOYBN (6)
A0A0R4J3C9_SOYBN (6)
C6TF57_SOYBN (6)
A0A0R0K7S9_SOYBN (6)
I1JXJ3_SOYBN (6)
Q9GRG6 (5)

CHEBI ID

CHEBI:16027 (8)
CHEBI:14336 (6)
CHEBI:40595 (6)
CHEBI:28874 (6)
CHEBI:13389 (6)
CHEBI:57642 (6)
CHEBI:4170 (6)
CHEBI:15379 (6)
CHEBI:17754 (6)
CHEBI:17138 (6)
CHEBI:15361 (6)
CHEBI:17794 (6)
CHEBI:15422 (6)
CHEBI:16761 (6)
CHEBI:16908 (6)
CHEBI:16526 (6)
CHEBI:18021 (6)
CHEBI:17234 (6)
CHEBI:35490 (5)
CHEBI:17842 (5)
CHEBI:58273 (5)
CHEBI:58121 (5)
CHEBI:48928 (5)
CHEBI:18009 (5)
CHEBI:16474 (5)
CHEBI:30653 (3)
CHEBI:33942 (2)
CHEBI:28757 (2)
CHEBI:33842 (1)
CHEBI:57622 (1)

Metabolite Name

Glutathione (2)
LPE 16:1 (2)
LPE 18:1 (2)
Glucose 1-phosphate (2)
LPE 20:2 (2)
4-(4-hydroxyphenyl)sulfonylphenol (1)
NAD⁺ (1)
Glu-glu (1)
LPC 8:0 (1)
18-alpha-Glycyrrhetinic acid (1)
Lysopc 16:2 (1)
8(R)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic acid (1)
(+/-)-Equol (1)
2,3-Dinor-11alpha-prostaglandin F2alpha (1)
1-(5H-dibenzo[b,f]azepin-5-yl)ethan-1-one (1)
3,3-dimethyl-1-[4-(trifluoromethoxy)phenyl]piperidine-2,6-dione (1)
JWH 250 N-pentanoic acid metabolite (1)
Ethyl 2-cyano-3-[(2-oxoazepan-3-yl)amino]acrylate (1)
3,4-Methylenedioxy-¦Á-pyrrolidinopropiophenone (1)
PC (8:0/8:0) (1)
5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5-monophosphate (1)
5-[(benzoyloxy)methyl]-4,5,6-trihydroxycyclohex-2-en-1-yl benzoate (1)
2-{2-oxo-2-[(2-oxo-3-azepanyl)amino]ethoxy}acetic acid (1)
Trans-delta-2-11-Methyl-dodecenoic acid (1)
N1-[2-oxo-6-(1H-pyrrol-1-yl)-2H-chromen-3-yl]acetamide (1)
6-amino-1-(2-methylphenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (1)
6alpha-Naltrexol (1)
8-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one (1)
N4-[5-(2-pyridyl)-2-thienyl]morpholine-4-carboxamide (1)
17alpha-Methyl-androstan-3-hydroxyimine-17alpha-ol (1)

First Public Date

2025 (38)
2024 (25)
2026 (24)
2014 (18)
2023 (15)
2022 (14)
2021 (11)
2019 (11)
2017 (9)
2013 (8)
2020 (6)
2018 (5)
2016 (4)
2015 (4)

Modelling Approach

Ordinary differential equation model (7)
Constraint-based model (2)

Lab affiliation

Department of Immunology, Interfaculty Institute for Cell Biology, Eberhard Karls University Tübingen (2)
Department of Chemistry, Stanford ChEM-H (2)
The Institute of Medical Science, The University of Tokyo (2)
Sun Yat-sen University (2)
School of Chemistry and Biochemistry and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA (2)
The Rosalind Franklin Institute, Oxfordshire, OX11 0FA, UK Department of Pharmacology, University of Oxford, OX1 3QT, UK Department of Chemistry, University of Oxford, OX1 3TA, UK (2)
Department of Peptide-based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany (2)
1 Department of Biology, University of Crete, 714 09 Heraklion, Crete, Greece 2 Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece (1)
Department of Hepatobiliary Surgery, the First Affiliated Hospital(Southwest Hospital) of Army Military Medical University, Chongqing 400038, China. (1)
Staff Scientist, Department of Clinical Biochemistry, University Health Network, Toronto, Canada Assistant Professor, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Canada (1)
1. Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark; 2. Proteomics and Singal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany (1)
Department of Peptide-based Immunotherapy, University and University Hospital Tuebingen, Germany (1)
Department of Peptid-based Immunotherapy, University and University Hospital TÃƒÆ’Ã‚Â¼bingen, Germany (1)
Traumatic Brain Injury Research, Roskamp Institute, Sarasota, FL, USA (1)
Departamento de Produtos Naturais, Laboratório de Bioquímica de Proteases e Inibidores de Proteases Naturais e Sintéticos, Fundação Oswaldo Cruz (Fiocruz),Brasil (1)
Roskamp Institute, Neurodegenerative Disease and Proteomics Lab, Sarasota, FL (1)
Department of Microbiology, Immunology and Pathology; Colorado State University, Fort Collins, CO (1)
Institute of Molecular Biosciences, Mahidol University, Thailand (1)
Professor, Dept. of Molecular Medicine The Scripps Research Institute Phone: (858) 784-8863 10550 North Torrey Pines Road, SR-302, La Jolla, CA 92037 (1)
Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy (1)
Pfizer, INC. (1)
Director, Mass Spectrometry & Proteomics Core, City of Hope, Beckman Research Institute, Diabetes & Metabolism Research Institute, Department of Molecular Imaging and Therapy, (1)
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences (1)
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal INEB - Instituto Nacional de Engenharia Biomédica, Universidade do Porto, 4200-135 Porto, Portugal (1)
SYNMIKRO, Zentrum für Synthetische Mikrobiologie, Philipps Universität Marburg, Karl-von-Frisch-Str. 14, 35043 Marburg, Germany Max-Planck-Institut für Terrestrische Mikrobiologie, Karl-von-Frisch Straße 16, 35043 Marburg, Germany (1)
Prof. Dr. Hadi Al-Hasani Direktor Institut für Klinische Biochemie und Pathobiochemie Deutsches Diabetes-Zentrum (DDZ) Leibniz-Zentrum für Diabetes-Forschung an der Heinrich-Heine-Universität Düsseldorf Auf´m Hennekamp 65 40225 Düsseldorf (1)
Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark. (1)
Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo University, Ningbo 315211, Zhejiang, China (1)
Associate Professor Glyco MS Group Copenhagen Center for Glycomics (CCG) Department of Cellular and Molecular Medicine University of Copenahgen Blegdamsvej 3 2200 Copenhagen N Denmark (1)
Department of Molecular Imaging and Therapy, Diabetes and Metabolism Research Institute, Beckman Research Institute of the City of Hope, USA Mass Spectrometry & Proteomics Core Facility, Beckman Research Institute of the City of Hope, USA (1)

IsPrivate

False (11)

Model Flag

Non Kinetic (4)

Submitter Keywords

FROG (1)

Classification

bacteria (3)
fungi (1)
protozoa (1)

Modification

2x(15)N labeled L-lysine (2)
N6 (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (71)
ChIP-seq (20)
Comparative genomic hybridization by array (17)
RNA-seq of coding RNA (14)
ChIP-chip by tiling array (5)
RNA-seq of non coding RNA (5)
Methylation profiling by high throughput sequencing (4)
Methylation profiling by array (3)
Unknown experiment type (2)
DNA-seq (2)
Proteomic profiling by array (2)
RNA-seq of total RNA (2)
One-color microarray (1)
High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
Genotyping by array (1)
MicroRNA profiling by array (1)
RNA-seq of coding RNA from single cells (1)

Release Date

2025 (177)
2022 (161)
2021 (145)
2023 (130)
2024 (126)
2020 (125)
2019 (111)
2018 (94)
2016 (92)
2014 (86)
2015 (83)
2017 (78)
2013 (74)
2012 (58)
2011 (55)
2010 (50)
2009 (35)
2026 (32)
2008 (27)
2006 (11)
2005 (8)
2007 (7)
2003 (5)
2002 (4)
2004 (2)
2000 (2)
2001 (1)
1997 (1)

Previous page
1 / 238
You're on page 1
page 2
page 3
page 4
page 5
page ...
page 238
Next page

Sort by:

Relevance

Page size

New workflow predicts drug targets against SARS-CoV-2 via metabolic changes in infected cells

COVID-19 is one of the deadliest respiratory diseases, and its emergence caught the pharmaceutical industry off guard. While vaccines have been rapidly developed, treatment options for infected people remain scarce, and COVID-19 poses a substantial global threat. This study presents a novel workflow...

2024-04-18 | MODEL2202240001 | BioModels

FROG

Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling.

Not available

S-EPMC5864104 | biostudies-literature

Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

Poly (ADP-ribose) polymerase 7 (PARP-7) has emerged as a critically important member of a large enzyme family that catalyze ADP-ribosylation in mammalian cells. PARP-7 is a critical regulator of the innate immune response. What remains unclear is the mechanism by which PARP-7 regulates this process,...

ORGANISM(S): Homo sapiens (Human)

2021-07-21 | PXD020323 | Pride

Chemical genetics Marylation Parp-7 Protein-protein interactions Enzymatic targets

Plasminogen small RNA cargo promotes immunogenicity and inhibits enzymatic activity

PRJNA1217466 | ENA

Enzymatic Metabolic Switches of Astrocyte Response to Lipotoxicity as Potential Therapeutic Targets for Nervous System Diseases.

Not available

S-EPMC11124372 | biostudies-literature

Bazzani2012 - Genome scale networks of P.falciparum and human hepatocyte

Bazzani2012 - Genome scale networks of P.falciparum and human hepatocyte This model is described in the article: Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism. ...

2005-01-01 | MODEL1206070000 | BioModels

Plasminogen small RNA cargo promotes immunogenicity and inhibits enzymatic activity [7369-DM]

PRJNA1217820 | ENA

Argentilactone molecular targets in Paracoccidioides brasiliensis identified by chemoproteomics

Paracoccidioidomycosis (PCM) is the cause of several deaths from systemic mycoses. The etiological agents of PCM belong to the Paracoccidioides genus, which is restricted to Latin America. The infection is acquired through inhalation of conidia that primarily lodges in the lungs and may disseminate ...

ORGANISM(S): fungal sp. 5OL6-6PL1

2018-02-07 | PXD008858 | Pride

Paracoccidioides Targets Argentilactone Antifungal Chemoproteomic

RNA Targets and Function of Topoisomerase 3β in Reducing Stress in Neuronal Physiology

PRJNA1049014 | ENA

A recombinant fusion toxin based on enzymatic inactive C3bot1 selectively targets macrophages.

Not available

S-EPMC3549961 | biostudies-literature

Previous page
1 / 238
You're on page 1
page 2
page 3
page 4
page 5
page ...
page 238
Next page

Sort by:

Relevance

Page size

2374 Results

Show results for

Organisms

Organisms

Repository

Tissue

Disease

Technology Type

Instrument Platform

Publication Date

UNIPROT ID/AC

CHEBI ID

Metabolite Name

First Public Date

Modelling Approach

Lab affiliation

Tags

IsPrivate

Model Flag

Submitter Keywords

Classification

Modification

Study type

Release Date

OmicsDI is part of the ELIXIR infrastructure

Tweets