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ProteomicsChemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets
Poly (ADP-ribose) polymerase 7 (PARP-7) has emerged as a critically important member of a large enzyme family that catalyze ADP-ribosylation in mammalian cells. PARP-7 is a critical regulator of the innate immune response. What remains unclear is the mechanism by which PARP-7 regulates this process,...
ORGANISM(S): Homo sapiens (Human) 
2021-07-21 | PXD020323 | Pride
Chemical genetics Marylation Parp-7 Protein-protein interactions Enzymatic targets 
ProteomicsChemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets
Poly(ADP-ribose) polymerase 7 (PARP7) has emerged as a critically important member of a large enzyme family that catalyze mono-ADP-ribosylation (MARylation) in mammalian cells. Unlike other PARPs, PARP7 is expressed in many different cell types and is upregulated by diverse stimuli, such as toxins, ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD020340 | Pride
Adpr Ptm Post-translational modification Parp7 Adp-ribosylation 
UnknownRACK1 MARylation regulates translation and stress granules in ovarian cancer cells.
Not available
S-EPMC11702359 | biostudies-literature
UnknownPARP10 Multi-Site Auto- and Histone MARylation Visualized by Acid-Urea Gel Electrophoresis.
Not available
S-EPMC7998796 | biostudies-literature
UnknownMARTs and MARylation in the Cytosol: Biological Functions, Mechanisms of Action, and Therapeutic Potential.
Not available
S-EPMC7913519 | biostudies-literature
UnknownChemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
Not available
S-EPMC7880690 | biostudies-literature
UnknownA PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Ovarian Cancer Cells.
Not available
S-EPMC10592810 | biostudies-literature
OtherA PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Cancer Cells [Ribo-seq]
In this study we examine the role of RACK1 MARylation in stress granule assembly and translational regulation in ovarian cancer cells. In addition, we describe the role of TARG1, an ADPR hydrolase enzyme in stress granule assembly and translation.
ORGANISM(S): Homo sapiens 
2025-01-02 | GSE245503 | GEO
TranscriptomicsA PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Cancer Cells [RNA-seq]
In this study we examine the role of RACK1 MARylation in stress granule assembly and translational regulation in ovarian cancer cells. In addition, we describe the role of TARG1, an ADPR hydrolase enzyme in stress granule assembly and translation.
ORGANISM(S): Homo sapiens 
2025-01-02 | GSE245502 | GEO
GenomicsA PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Cancer Cells [Ribo-seq]
A PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Cancer Cells [Ribo-seq]
PRJNA1028618 | ENA
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