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ProteomicsEPAC1 knockout mouse effects in platelets and plasma
ABSTRACT FOR BOTH PLASMA AND PLATELET-LYSATE In this article we describe the involvement of exchange factor activated by cAMP 1 (Epac1) in hemostasis and platelet activation. We have used plasma and platelet-lysate from EPAC1 knockout mice and wild-type control mice in label-free proteomics with an ...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-25 | PXD000282 | Pride
Epac1 knockout Platelets Lc-ms Plasma Label-free 
TranscriptomicsEndothelial Epac1 facilitates YAP/TAZ controlled melanoma growth and angiogenesis
Mice were treated by 75 mg/kg BW/day tamoxifen intraperitoneally for 5 days to induce endothelial specific Epac1/Rapgef3 knockout. This knockout allows us to study the role of endothelial Epac1 in tumor angiogenesis in mice inoculated subcutaneously with B16-F10 melanoma. Tumour endothelial cells we...
ORGANISM(S): Mus musculus 
2026-09-30 | GSE341674 | GEO
GenomicsSingle-cell RNA sequencing reveals that Epac1 deletion attenuates Müller glial pathological activation in ischemia-induced retinopathy
Single-cell RNA sequencing reveals that Epac1 deletion attenuates Müller glial pathological activation in ischemia-induced retinopathy
PRJNA1453907 | ENA
TranscriptomicsSingle-cell RNA sequencing reveals that Epac1 deletion attenuates Müller glial pathological activation in ischemia-induced retinopathy
Here we report the single-cell RNA sequencing (scRNA-seq) analysis of retinas from WT and Epac1-knockout mice under Oxygen-Induced Retinopathy (OIR) and Room Air (RA) conditions. The OIR model was induced by exposing pups to 70% oxygen from postnatal day 7 (P7) to P12. This study aims to delineate t...
ORGANISM(S): Mus musculus 
2026-04-15 | GSE328096 | GEO
UnknownElevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion.
Not available
S-EPMC5828986 | biostudies-literature
UnknownEpac1 activation by cAMP regulates cellular SUMOylation and promotes the formation of biomolecular condensates.
Not available
S-EPMC9020664 | biostudies-literature
UnknownEpac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling.
Not available
S-EPMC6938696 | biostudies-literature
UnknownInhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation.
Not available
S-EPMC9992743 | biostudies-literature
UnknownUpregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis.
Not available
S-EPMC10476449 | biostudies-literature
UnknownEpac1 Is Crucial for Maintenance of Endothelial Barrier Function through A Mechanism Partly Independent of Rac1.
Not available
S-EPMC7601253 | biostudies-literature
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