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TranscriptomicsAnalysis of the gene expression profile in cutaneous squamous cell carcinoma cells after EphB2 knockdown
The role of Eph/ephrin signaling in numerous biological processes has been established. However, Eph/ephrin signaling has been shown to have complex role in tumor progression. The role of EphB2 receptor in the progression of cutaneous squamous cell carcinoma (cSCC) has not been studied before. EphB2...
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-66361 | biostudies-arrayexpress
ProteomicsUbiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes during development and throughout adulthood. This versatility is likely facilitated by the ability of Eph receptors to signal through diverse cellular signalling pathways: primarily by controlling cytoskeletal ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-29 | PXD041786 | Pride
Ap-ms Ephb2 Lc-ms/ms 
TranscriptomicsIsolation and in vitro expansion of human colonic stem cells [Expression profile]
Using the surface marker EPHB2, we have FACS-purified and profiled stem cell-enriched cell fractions from normal human mucosa, crypt proliferative progenitors and late transient amplifying cells to define a gene expression program specific for normal human colon epithelial stem cells We FACS purifie...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31255 | biostudies-arrayexpress
TranscriptomicsTranscriptional targets of EphB2 and Ephrin-A4 signaling in epidermal keratinocytes
Human epidermal keratinocytes were treated with 25 ng.ml EphB2 or EFNA4, both as-Fc conjugates (Sigma). Human epidermal keratinocytes are treated with 25 ng/ml EphB2 or EFNA4 Fc conjugates in a 48hr time course.
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-26523 | biostudies-arrayexpress
TranscriptomicsEphB2 promotes progression of cutaneous squamous cell carcinoma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-66368 | biostudies-arrayexpress
TranscriptomicsThe intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
Using EphB2 or the ISC marker Lgr5, we have FACS-purified and profiled intestinal stem cells (ISCs), crypt proliferative progenitors and late transient amplifying cells to define a gene expression program specific for normal ISCs. A frequent complication in colorectal cancer (CRC) is regeneration of...
ORGANISM(S): Mus musculus 
2011-03-14 | E-GEOD-27605 | biostudies-arrayexpress
GenomicsEphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis
EphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis
PRJNA1064021 | ENA
TranscriptomicsThe comparison of gene expression profile in the amygdalae between the wild-type and neuropsin knock-out mice
Extracellular proteolysis contributes to fear-associated responses by facilitating neuronal plasticity at the neuron-matrix interface. A serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the strength of EphB2/NMDA receptor interaction controlling the e...
ORGANISM(S): Mus musculus 
2011-05-13 | E-GEOD-27088 | biostudies-arrayexpress
TranscriptomicsEphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis
Objectives: Eph/Ephrin cell-cell signaling is emerging as a key player in tissue fibrogenesis. The aim of this study was to test the hypothesis that the receptor tyrosine kinase EphB2 mediates dermal fibrosis in systemic sclerosis (SSc). Methods: We assessed normal and SSc human skin biopsies for Ep...
ORGANISM(S): Homo sapiens 
2024-04-10 | GSE253089 | GEO
GenomicsHepatocytes demarcated by EphB2 contribute to the progression of non-alcoholic steatohepatitis
Hepatocytes demarcated by EphB2 contribute to the progression of non-alcoholic steatohepatitis
PRJNA783863 | ENA
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