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MetabolomicsCell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
ProteomicsDppa2/4 target chromatin bivalency enabling multi-lineage commitment
Epigenetic priming factors establish a permissive epigenetic landscape which is not required until a later developmental or physiological time point, temporally uncoupling the presence of these factors with their phenotypic effects. One classic example of epigenetic priming is in the context of biva...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD014981 | Pride
Qplex rime Epigenetic priming Compass Bivalency Development Trithorax 
TranscriptomicsAtherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells
Single-cell RNA sequencing revealed a dysregulated myeloid immune response with hyperinflammatory and immunosuppressive features in patients with ASCVD and moderate COVID-19. Assay for Transposase-Accessible Chromatin sequencing and in-vitro experiments with isolated monocytes infected with SARS-CoV...
ORGANISM(S): Homo sapiens 
2025-01-15 | E-MTAB-16472 | biostudies-arrayexpress
GenomicsEpigenetic priming of embryonic enhancer elements coordinates developmental gene networks [scPBAT]
Epigenetic priming of embryonic enhancer elements coordinates developmental gene networks [scPBAT]
PRJNA1174788 | ENA
GenomicsEpigenetic priming of embryonic enhancer elements coordinates developmental gene networks [scNMT]
Epigenetic priming of embryonic enhancer elements coordinates developmental gene networks [scNMT]
PRJNA1174790 | ENA
GenomicsEpigenetic priming by Dppa2/4 in pluripotency facilitates multi-lineage commitment
Epigenetic priming by Dppa2/4 in pluripotency facilitates multi-lineage commitment
PRJNA560249 | ENA
GenomicsStage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [CUT&Run]
Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [CUT&Run]
PRJNA1267101 | ENA
GenomicsStage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [RELACS]
Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [RELACS]
PRJNA1267103 | ENA
GenomicsStage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [4C]
Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [4C]
PRJNA1267093 | ENA
GenomicsStage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [Multiome]
Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [Multiome]
PRJNA1267109 | ENA
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