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TranscriptomicsGene Expression Profiling for Plk2 -/- mammary gland
Identify gene expression changes in the absence of Plk2 Disruptions in polarity and mitotic spindle orientation contribute to the progression and evolution of tumorigenesis. However, little is known about the molecular mechanisms regulating these processes in vivo. Here we demonstrate that Polo-like...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-50003 | biostudies-arrayexpress
ProteomicsPlanar Cell Polarity Core Protein Vangl
Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along the epithelial plane perpendicular to the apical-basal direction, which is important for tissue morphogenesis, development and collective cell behavior.
ORGANISM(S): Homo Sapiens 
PXD054233 |
TranscriptomicsThe epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate alternative splicing events
Epithelial Splicing Regulatory Proteins 1 and 2 (ESRP1 and ESRP2) are recently discovered epithelial-specific RNA-binding proteins that promote splicing of the epithelial variant of the FGFR2, ENAH, CD44, and CTNND1 transcripts. To catalogue a larger set of splicing events under the regulation of t...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17468 | biostudies-arrayexpress
GenomicsBEAF-32 insulator regulates gene expression of genes involved in cell polarity and neoplastic growth.
This SuperSeries is composed of the following subset Series: GSE36735: Distribution of Drosophila insulator protein BEAF-32 in Wing imaginal tissue (Wildtype) [ChIP-seq] GSE36736: Genome wide transcriptional profiling of BEAF-32 in wing imaginal tissues of wildtype and mutants [expresion array] Refe...
ORGANISM(S): Drosophila melanogaster 
2012-07-05 | E-GEOD-36737 | biostudies-arrayexpress
TranscriptomicsCaco2 polarization time-course
CELL CULTURE: The human intestinal epithelial cell line Caco-2 (obtained from Dr. Stanley Falkow, Stanford University) was used to study the genome-wide expression program underlying the transition from cell proliferation to establishment of a polarized epithelial layer. Cells were first grown in sp...
ORGANISM(S): Homo sapiens 
2007-08-16 | E-GEOD-7442 | biostudies-arrayexpress
UnknownAutonomous epithelial folding induced by an intracellular mechano-polarity feedback loop.
Not available
S-EPMC8675927 | biostudies-literature
GenomicsDistribution of Drosophila insulator protein BEAF-32 in Wing imaginal tissue (Wildtype) [ChIP-seq]
Chromatin insulators are DNA protein complexes that mediate inter and intra chromosomal interactions. Boundary Element Associated Factor- 32 (BEAF-32) is an insulator protein predominantly found near gene promoters and thought to play a role in gene expression. We find that mutations in BEAF-32 are ...
ORGANISM(S): Drosophila melanogaster 
2012-07-05 | E-GEOD-36735 | biostudies-arrayexpress
UnknownClaudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
Not available
S-EPMC6781433 | biostudies-literature
TranscriptomicsTranscription profiling by array of mouse Cdx2 knock out intestinal epithelium
RNAs were extracted from E18.5 control and Cdx2/villin-cre mutant ileums. We aim to identify the gene network changes in the mutant epithelia. We are especially interested in genes related with proliferation, apoptosis and cell differentiation.
ORGANISM(S): Mus musculus 
2010-06-23 | E-MTAB-218 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila melanogaster at multiple developmental stages to examine morphogenesis of epithelial tissue
Morphogenesis of epithelial tissues relies on the precise developmental control of cell polarity and architecture. In the early Drosophila embryo, the primary epithelium forms during cellularisation, following a tightly controlled genetic programme where specific sets of genes are up-regulated. Some...
ORGANISM(S): Drosophila melanogaster 
2007-10-31 | E-GEOD-3955 | biostudies-arrayexpress
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