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UnknownStructural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2.
Not available
S-EPMC4646255 | biostudies-literature
UnknownInhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2.
Not available
S-EPMC8842112 | biostudies-literature
TranscriptomicsCell-specific and spatio-temporal controls of the estrogen-responsive trefoil factor (TFF) locus activity
Cell-specific transcriptional regulations exerted by the estrogen (E2) receptor alpha (ER) heavily rely upon timely and spatially coordinated processes. We engaged a comparative analysis of such dynamic molecular events at the TFF locus harbouring a cluster of genes co-regulated by E2, in two distin...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-32132 | biostudies-arrayexpress
TranscriptomicsCell-specific and spatio-temporal controls of the estrogen-responsive trefoil factor (TFF) locus activity.II.
Cell-specific transcriptional regulations exerted by the estrogen (E2) receptor alpha (ER) heavily rely upon timely and spatially coordinated processes. We engaged a comparative analysis of such dynamic molecular events at the TFF locus harbouring a cluster of genes co-regulated by E2, in two distin...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-23850 | biostudies-arrayexpress
GenomicsChIP-Seq of human breast cancer cell lines with antibodies FOXA1, ER and CTCF
Growth cells and map of ER, FoxA1 and CTCF binding at whole genome level
ORGANISM(S): Homo sapiens 
2011-02-01 | E-MTAB-223 | biostudies-arrayexpress
ProteomicsAn ERAP2 inhibitor induces cell-surface presentation of many new and potentially antigenic peptides by cancer cells
Recent studies have linked the activity of ER aminopeptidase 2 (ERAP2) to increased efficacy of immune-checkpoint inhibitor cancer immunotherapy, suggesting that pharmacological inhibition of ERAP2 could have important therapeutic implications. To explore the effects of ERAP2 inhibition on the immun...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD029895 | Pride
Inhibitor Dg011a Mhci Molt4 Er aminopeptidase 2 Erap2 Immunopeptidomics 
TranscriptomicsModeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer [RNA-Seq]
Estrogen receptor-α (ERα) is an important driver of breast cancer and is the target for hormonal therapies, anti-estrogens and drugs that limit estrogen biosynthesis (aromatase inhibitors). Mutations in the ESR1 gene identified in metastatic breast cancer provide a potential mechanism for acquired...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78285 | biostudies-arrayexpress
GenomicsSRC-1 targets ADAM22: an ER-independent mechanism of tumour progression in endocrine resistance
We profile the binding of Steroid Receptor Co-activator (SRC1) in LY2 cells, a tamoxifen-resistant cell line, in the presence and absence of tamoxifen using ChIP-sequencing technology. The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity le...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-28987 | biostudies-arrayexpress
GenomicsChIP-seq of MDA-MB-134 cell line
We performed ChIP seq experiment in MDA-MB-134 cell line in order to map the estrogen receptor alpha (ER) binding sites following the estrogen treatment in an ILC model. We have characterized the genome wide recruit of ER and scaned the binding sites for the presence of cofactor motifs. The binding ...
ORGANISM(S): Homo sapiens 
2014-01-15 | E-GEOD-51022 | biostudies-arrayexpress
GenomicsModeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer [ChIP-Seq]
Estrogen receptor-α (ERα) is an important driver of breast cancer and is the target for hormonal therapies, anti-estrogens and drugs that limit estrogen biosynthesis (aromatase inhibitors). Mutations in the ESR1 gene identified in metastatic breast cancer provide a potential mechanism for acquired...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78284 | biostudies-arrayexpress
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