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MetabolomicsSimultaneous Membrane and RNA Binding by Tick-Borne Encephalitis Virus Capsid Protein

Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the endoplasmic reticulum membrane and acquires ...

2023-01-06 | MTBLS6076 | MetaboLights
ProteomicsMammalian MemPrep establishes the lipid composition ER membranes in HEK293T cells
Mammalian MemPrep is an approach that enables the isolation of ER membranes from HEK293T cells at a purity suitable for quantitative proteomics and lipidomics. Using cleavable, epitope‑tagged variants of SEC61β and REEP5, which preferentially localize to ER sheets and tubules, respectively, we isola...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD075836 | Pride
Er membrane composition Immunoisolation Mammalian cells Memprep Differential centrifugation 
ProteomicsAn ERAD independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis
Nearly one-third of nascent proteins are initially targeted to the endoplasmic reticulum (ER) where they are correctly folded and assembled before being delivered to their final cellular destinations. To prevent the accumulation of misfolded membrane proteins, ER-associated-degradation (ERAD) remove...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
MSV000090333 | MassIVE
ProteomicsComparative membrane proteomics reveals diverse cell regulators concentrated at the nuclear envelope
The nuclear envelope (NE) is a subdomain of the ER with a distinctive protein composition that underpins its role in nuclear compartmentalization. To expand an understanding of NE functions, we refined methods to reveal low abundance transmembrane (TM) proteins concentrated at the NE. De facto, th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-25 | MSV000091154 | MassIVE
TranscriptomicsEstrogen inhibits lipid content in liver exclusively from membrane receptor signaling
Membrane estrogen receptor (ER) alpha stimulates AMP kinase to suppress SREBP1 processing and lipids in liver Here we present evidence that signaling from membrane-localized ERalpha similarly suppresses a subset of mRNAs in the livers of female WT and membrane only estrogen receptor (MOER) transgeni...
ORGANISM(S): Mus musculus 
2013-05-14 | E-GEOD-45346 | biostudies-arrayexpress
ProteomicsThe p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition
The intimate association between the endoplasmic reticulum (ER) and mitochondrial membranes at ER-mitochondria contact sites (ERMCS) serves as a platform for several critical cellular processes, particularly lipid synthesis. How contacts are remodeled and the subsequent biological consequences of al...
ORGANISM(S): Homo sapiens (Human) 
2023-01-25 | PXD039061 | Pride
Srebp1 Ermcs Scd1 Ubxd8 Neurodegeneration 
UnknownPalmitate and thapsigargin have contrasting effects on ER membrane lipid composition and ER proteostasis in neuronal cells.
Not available
S-EPMC9452468 | biostudies-literature
TranscriptomicsCharacterization of macrophage - cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer
We performed whole transcriptome sequencing of human monocytes that were co-cultured with estrogen receptor positive (ER+) or triple-negative (TNBC) breast cancer cell lines and studied the biological responses related to the differential gene activation in both cell types to understand how differen...
ORGANISM(S): Homo sapiens 
2015-11-19 | E-GEOD-75130 | biostudies-arrayexpress
GenomicsTransient ER binding and p300 redistribution support a physiological squelching model for immediate ER-repressed genes
Selective transcriptional activation and repression of genes throughout signaling cascades and development are poorly understood. Transcription factors (TF) orchestrate patterns and magnitude of transcriptional response, but TF action, or inaction, is highly dependent upon TF kinetics, distance from...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-54855 | biostudies-arrayexpress
TranscriptomicsThe EBV latent membrane protein 1 (LMP1) induces cellular microRNA-146a, a modulator of lymphocyte signaling pathways
This SuperSeries is composed of the following subset Series: GSE10057: The Epstein-Barr Virus latent membrane protein 1 (LMP1) induces cellular microRNA146a GSE10105: Alteration of microRNA gene expression by EBV encoded LMP1 oncogene Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Homo sapiens 
2008-01-08 | E-GEOD-10107 | biostudies-arrayexpress
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