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ProteomicsThe p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition
The intimate association between the endoplasmic reticulum (ER) and mitochondrial membranes at ER-mitochondria contact sites (ERMCS) serves as a platform for several critical cellular processes, particularly lipid synthesis. How contacts are remodeled and the subsequent biological consequences of al...
ORGANISM(S): Homo sapiens (Human) 
2023-01-25 | PXD039061 | Pride
Srebp1 Ermcs Scd1 Ubxd8 Neurodegeneration 
OtherBRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
Inter-organellar communication is critical for cellular metabolic homeostasis. One of the most abundant inter-organellar interactions are those at the endoplasmic reticulum and mitochondria contact sites (ERMCS). However, a detailed understanding of the mechanisms governing ERMCS regulation and thei...
ORGANISM(S): Homo sapiens 
2026-03-24 | GSE278077 | GEO
ProteomicsThe ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)
Our study demonstrates that ERMCS-localized TMX2 enhances the antioxidant activity of PRDX1/2 on TOM70, thereby preventing sulfenylation of TOM70 at C206 and regulating mitochondrial metabolism.
ORGANISM(S): Homo Sapiens (human) 
2025-10-31 | PXD057380 | JPOST Repository
GenomicsBRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
Inter-organellar communication is critical for cellular metabolism. One of the most abundant inter-organellar interactions occurs at the endoplasmic reticulum and mitochondria contact sites (ERMCSs). However, an understanding of the mechanisms governing ERMCS regulation and their roles in cellular m...
ORGANISM(S): Homo sapiens 
2026-03-25 | GSE280900 | GEO
ProteomicsBRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III
Inter-organellar communication is critical for cellular metabolic homeostasis. One of the most abundant inter-organellar interactions are those at the endoplasmic reticulum and mitochondria contact sites (ERMCS). However, a detailed understanding of the mechanisms governing ERMCS regulation and thei...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD056917 | Pride
Endoplasmic reticulum-mitochondria contact sites Bromodomain protein Mitochondrial electron transport chain. High-throughput screening 
UnknownReduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines.
Not available
S-EPMC10514478 | biostudies-literature
UnknownCapture at the ER-mitochondrial contacts licenses IP3 receptors to stimulate local Ca2+ transfer and oxidative metabolism.
Not available
S-EPMC9646835 | biostudies-literature
UnknownDeregulation of ER-mitochondria contact formation and mitochondrial calcium homeostasis mediated by VDAC in fragile X syndrome.
Not available
S-EPMC10113018 | biostudies-literature
UnknownStructural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.
Not available
S-EPMC9239997 | biostudies-literature
UnknownAltered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models.
Not available
S-EPMC6156612 | biostudies-literature
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