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TranscriptomicsExpression data in PD-L1 positive and PD-L1 negative human melanoma samples
Blocking the PD-1/PD-L1 immunosuppressive pathway has shown promise in the treatment of certain cancers including melanoma. This study investigates differences in the gene expression profiles of human melanomas that do or do not display the immunosuppressive protein PD-L1. Further understanding of g...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-65041 | biostudies-arrayexpress
TranscriptomicsIntegrated molecular genetic profiling of pediatric-high grade gliomas reveals key differences with adult disease
Purpose: To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). Patients and Methods: We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGG, including 7 diffuse intrinsic pontine gliomas, and 10 HGG cases ar...
ORGANISM(S): Homo sapiens 
2010-06-15 | E-GEOD-19578 | biostudies-arrayexpress
TranscriptomicsExpression of JNK target genes during dorsal closure of the Drosophila embryo
Morphogenesis of an epithelium relies on the differentiation of cellular territories that further adopt specific cell behavior. During dorsal closure of the Drosophila embryo, distinct territories and several signaling pathways (JNK, Wingless, Dpp, …) bring their own contribution to the migration of...
ORGANISM(S): Drosophila melanogaster 
2010-07-07 | E-GEOD-21805 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of purified populations of normal human breast luminal and myoepithelial cells
Purified populations of normal human breast luminal and myoepithelial cells were compared with cDNA microarray analysis.
ORGANISM(S): Homo sapiens 
2004-05-04 | E-MEXP-36 | biostudies-arrayexpress
TranscriptomicsComprehensive analysis of host gene expression in Autographa californica nucleopolyhedrovirus-infected Spodoptera frugiperda cells
Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) is the best-studied baculovirus and most commonly used virus vector for baculovirus expression vector systems. The effect of AcMNPV infection on host cells is incompletely understood. A microarray based on Spodoptera frugiperda ESTs wa...
ORGANISM(S): Spodoptera frugiperda 
2014-08-26 | E-GEOD-60739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung from individuals with airway hyperactivity and goblet cell metaplasia post-Sendai virus infection
Mice representing phenotypic extremes of airway hyperreactivity and goblet cell metaplasia post-Sendai virus infection were identified from a 500 mouse F2 cohort (CB6F2/J). Whole lung RNA from 3 mice at each extreme was analyzed via microarray for gene expression. Subsequent pairwise comparisons b...
ORGANISM(S): Mus musculus 
2007-07-06 | E-GEOD-3925 | biostudies-arrayexpress
TranscriptomicsOverexpression of Musashi1 (Msi1) in HEK293T cells.
Gene expression analysis of the Msi1 overexpression in HEK 293T cells. There were two biological replicates of Msi1 and GFP (Green Fluorescent Protein) as control, used in the experiment. Each slide includes 4 microarrays with one biological sample versus control. Samples were hybridized with dye-...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-13215 | biostudies-arrayexpress
TranscriptomicsMolecular events of apical bud formation in white spruce
Bud formation is an adaptive trait that temperate forest trees have acquired to facilitate seasonal synchronization. We have characterized transcriptome-level changes that occur during bud formation of white spruce (Picea glauca [Moench] Voss.), a primarily determinate species in which preformed ste...
ORGANISM(S): Picea glauca 
2010-12-01 | E-GEOD-23519 | biostudies-arrayexpress
TranscriptomicsEffects of Arid1a knockout in murine ovarian endometrioid carcinomas with biallelic inactivation of Apc and Pten
We mated mice with floxed alleles of both Apc and Pten, to mice with floxed alleles for Arid1a, to obtain female mice with both copies of all three genes floxed. At 7 to 8 weeks of age the right ovarian bursal cavites of the mice were injected with 50 million plaque-forming units of adenovirus expr...
ORGANISM(S): Mus musculus 
2015-08-04 | E-GEOD-67695 | biostudies-arrayexpress
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