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TranscriptomicsTranscription profiling of Ercc1 white adipose tissue
Transcriptome analysis of epididymal white adipose tissue (WAT) depots in Ercc1 animals: To further elucidate the role of ERCC1 in WAT we scanned the transcriptome of 15 day old wt and Ercc1 epididymal WAT.
ORGANISM(S): Mus musculus 
2013-11-04 | E-MEXP-3930 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Ercc1-/- and age-matched wt pancreata
Total RNA was isolated from wt and Ercc1-/- pancreata from 15 days old C57BL/6J wt and Ercc1-/- mice
ORGANISM(S): Mus musculus 
2021-05-15 | E-MTAB-10393 | biostudies-arrayexpress
ProteomicsTwo siblings with strong NER inactivation due to inherited ERCC1 deficiency display mild clinical features of XP and CS with severe liver impairment
The ERCC1-XPF heterodimer is a multifunctional endonuclease involved in nucleotide excision repair (NER), inter-strand crosslink (ICL) repair, and DNA double-strand break (DSB) repair. Only two patients with inherited ERCC1 defects have been reported who both died at an early age. Here, we describe ...
ORGANISM(S): Homo sapiens (Human) 
2021-01-26 | PXD017940 | Pride
Nucleotide excission repair Ercc1 Cockayne syndrome Xeroderma pigmentosum 
TranscriptomicsIdentification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress
We compared microRNA (miRNA) expression in Ercc1-/- primary mouse embryonic fibroblasts (MEFs) and wild-type (WT) MEFs in 20% O2 and 3% O2 growth conditions to identify miRNAs that drive cellular senescence. MicroRNA expression in WT and Erccc1-/- MEFs was measured at passage 3 and passage 7 after g...
ORGANISM(S): Mus musculus 
2013-06-29 | E-GEOD-48417 | biostudies-arrayexpress
GenomicsGene expression profiling of Ercc1-/- and age-matched wt pancreata
Gene expression profiling of Ercc1-/- and age-matched wt pancreata
PRJEB44570 | ENA
TranscriptomicsTranscription profiling of liver from Ercc1-/- mice and wild type littermates to investigate features of premature aging
To investigate the cause of the premature aging features in the Ercc1-/- mouse, we compared the entire transcriptome of the Ercc1-/- mouse liver to that of wildtype littermates at the age of 15 days, when the Ercc1-/- mice reached their maximal weight and had symptoms of progeria, yet overall pathol...
ORGANISM(S): Mus musculus 
2006-12-21 | E-MEXP-834 | biostudies-arrayexpress
TranscriptomicsDown-regulation of cholesterol biosynthesis in forebrains of ERCC1-deficient mice
Background: Several genetic defects of the nucleotide excision repair (NER) pathway, including deficiency of the Excision Repair Cross-Complementing rodent repair deficiency, complementation group 1 (ERCC1), result in pre-mature aging, impaired growth, microcephaly and delayed development of the cer...
ORGANISM(S): Mus musculus 
2011-08-15 | E-GEOD-31199 | biostudies-arrayexpress
TranscriptomicsA systems approach identifies progeroid Ercc1[-/Δ] mice as a model system for kidney aging.
Using these samples, it has been shown that the transcriptional landscape in glomeruli of Ercc1[-/Δ] mice at a rather young age of 14 weeks mimics that of mice which have undergone real-life renal aging. Thus, young Ercc1[-/Δ] mice can be used as a model system for glomerular aging in future studies...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-43061 | biostudies-arrayexpress
ProteomicsERCC1-XPF Cooperates with CTCF and the Cohesin to Facilitate the Developmental Silencing of Imprinted Genes
Inborn defects in DNA repairare associated with complex developmental disorders whose causal mechanisms are poorly understood. Using an in vivo biotinylation tagging approach in mice, we show that the nucleotide excision repair (NER) structure-specific endonuclease ERCC1-XPF complex interacts with t...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-04 | PXD005897 | Pride
Levers Ap-ms In vivo biotinylation tagging Mouse Ner Label-free Ercc1-xpf 
GenomicsMutational consequences of ERCC1-deficiency in adult mouse stem cells
Mutational consequences of ERCC1-deficiency in adult mouse stem cells
PRJEB19368 | ENA
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