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ProteomicsERCC1-XPF Cooperates with CTCF and the Cohesin to Facilitate the Developmental Silencing of Imprinted Genes
Inborn defects in DNA repairare associated with complex developmental disorders whose causal mechanisms are poorly understood. Using an in vivo biotinylation tagging approach in mice, we show that the nucleotide excision repair (NER) structure-specific endonuclease ERCC1-XPF complex interacts with t...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-04 | PXD005897 | Pride
Levers Ap-ms In vivo biotinylation tagging Mouse Ner Label-free Ercc1-xpf 
TranscriptomicsRNA-Seq profiling of ERCC1-XPF DNA repair defect (Er1F/-) versus wild type (Er1F/+) macrophages
DNA damage and metabolic disorders are intimately linked with premature disease onset but the underlying mechanisms remain poorly understood. Persistent DNA damage accumulation in tissue-infiltrating macrophages carrying an ERCC1-XPF DNA repair defect (Er1F/-) riggers Golgi dispersal, dilation of en...
ORGANISM(S): Mus musculus 
2019-11-04 | E-MTAB-8439 | biostudies-arrayexpress
ProteomicsIdentification of a new XPF-ERCC1-like complex important for meiotic crossovers production
Proteins of the XPF-ERCC1 complex family play roles in DNA repair. Known members (four in mammals, two in budding yeast) recognize branched DNA structures and most bear nuclease activity. Here, we identified a new XPF-ERCC1-like complex important for meiotic crossovers production. Through a proteomi...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-04-10 | PXD007735 | Pride
Budding yeast Interactomics Meiotic recombination 
ProteomicsSLX4 and SLX4IP TAP-MS - SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair
Interstrand crosslinks (ICLs) are highly toxic DNA lesions, which are repaired via a complex process that requires the coordination of several DNA repair pathways. Defects in ICL repair result in Fanconi anemia (FA), which is diagnosed with bone marrow failure, development abnormalities and high inc...
ORGANISM(S): Homo sapiens (Human) 
2019-09-13 | PXD012521 | Pride
Sfb Slx4 Tap-ms Slx4ip 
UnknownAcetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation.
Not available
S-EPMC7005904 | biostudies-literature
GenomicsRNA-Seq profiling of ERCC1-XPF DNA repair defect (Er1F/-) versus wild type (Er1F/+) macrophages
RNA-Seq profiling of ERCC1-XPF DNA repair defect (Er1F/-) versus wild type (Er1F/+) macrophages
PRJEB34889 | ENA
UnknownERCC1/XPF limits L1 retrotransposition.
Not available
S-EPMC2483505 | biostudies-literature
UnknownERCC1-XPF endonuclease facilitates DNA double-strand break repair.
Not available
S-EPMC2519706 | biostudies-literature
UnknownDownregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells.
Not available
S-EPMC4331052 | biostudies-literature
UnknownRemoval of reactive oxygen species-induced 3'-blocked ends by XPF-ERCC1.
Not available
S-EPMC3221891 | biostudies-literature
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