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ProteomicsU2OS SLX4IP Knockout Telomere PICh
This experiment sought to characterize the perturbations to the telomere proteome brought about by modulation of SLX4IP expression, as we have previously found SLX4IP to act as a key regulator of telomere maintenance.
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD024141 | Pride
Telomeres Slx4ip Alt Pich 
ProteomicsSLX4 and SLX4IP TAP-MS - SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair
Interstrand crosslinks (ICLs) are highly toxic DNA lesions, which are repaired via a complex process that requires the coordination of several DNA repair pathways. Defects in ICL repair result in Fanconi anemia (FA), which is diagnosed with bone marrow failure, development abnormalities and high inc...
ORGANISM(S): Homo sapiens (Human) 
2019-09-13 | PXD012521 | Pride
Sfb Slx4 Tap-ms Slx4ip 
GenomicsSLX4IP limits replication stress globally and at ALT telomeres
SLX4IP limits replication stress globally and at ALT telomeres
PRJNA1271019 | ENA
GenomicsExpression data from parental and SLX4IP-depleted D2.OR cells
Expression data from parental and SLX4IP-depleted D2.OR cells
PRJNA517271 | ENA
GenomicsRNA-seq expression data from parental and SLX4IP-depleted D2.OR cells
RNA-seq expression data from parental and SLX4IP-depleted D2.OR cells
PRJNA825554 | ENA
GenomicsSLX4IP limits replication stress globally and at ALT telomeres
Faithful DNA replication is essential for genome stability, yet replication forks face constant stress. The Bloom syndrome helicase (BLM) safeguards fork integrity, but excessive BLM activity can itself induce replication stress. We identify SLX4IP as a genome-wide regulator that restrains BLM to ma...
ORGANISM(S): Homo sapiens 
2026-05-08 | GSE298728 | GEO
TranscriptomicsRNA-seq expression data from parental and SLX4IP-depleted D2.OR cells
SLX4IP mediates Hedgehog signaling through isoform-specific SUMOylation of GLI1 We sought to assess genome-wide transcriptomic and signaling changes induced by loss of SLX4IP in D2.OR breast cancer cells, which identified the Hedgehog pathways as being significantly disrupted by SLX4IP depletion
ORGANISM(S): Mus musculus 
2026-04-01 | GSE200622 | GEO
UnknownSLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance.
Not available
S-EPMC6863466 | biostudies-literature
TranscriptomicsExpression data from parental and SLX4IP-depleted D2.OR cells
Loss of SLX4IP elicits the metastatic outgrowth of nonmetastatic breast cancer cells by activating Wnt signaling to induce telomere maintenance mechanism switching We sought to assess genome-wide transcriptomic profiles governed by loss of SLX4IP expression in latent D2.OR breast cancer cells
ORGANISM(S): Mus musculus 
2019-01-27 | GSE125702 | GEO
UnknownSLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.
Not available
S-EPMC6821277 | biostudies-literature
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