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ProteomicsNascent alt-protein chemoproteomics reveals a repressor of ribosome biogenesisNascent alt-protein chemoproteomics reveals a repressor of pre-60S assembly
Many unannotated microproteins and alternative proteins (alt-proteins) have recently been found to be co-encoded with canonical proteins, but few of their functions are known. Motivated by the hypothesis that alt-proteins undergoing regulated synthesis could play important cellular roles, we develop...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD026880 | Pride
Human hek 293t Lc-ms/ms 
ProteomicsSignalling Inhibition by Ponatinib Disrupts Productive Alternative Lengthening of Telomeres (ALT)
Alternative lengthening of telomeres (ALT) supports telomere maintenance and replicative immortality in around 10-15% of cancers, thus representing a compelling target for therapy.To identify anti-cancer drugs that can be repurposed as ALT-centered therapies, we performed for a compound library scre...
ORGANISM(S): Homo sapiens (Human) 
2023-02-20 | PXD037501 | Pride
Telomeres Alt Ponatinib Sarcoma Jun 
ProteomicsAlt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
While thousands of previously unannotated small and alternative open reading frames (alt-ORFs) have recently been revealed in the human genome, the functions of only a handful are currently known, leaving open the question of their biological significance as a class. Using a proteomic strategy for d...
ORGANISM(S): Homo sapiens (Human) 
2020-12-07 | PXD018268 | Pride
Human microprotein alt-protein phosphoproteomics 
GenomicsDAXX Suppression of ALT
DAXX Suppression of ALT
PRJNA421229 | ENA
GenomicsDAXX Suppression of ALT
DAXX Suppression of ALT
PRJNA421228 | ENA
ProteomicsRAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA
Alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR) mechanism of telomere elongation that controls proliferation in subsets of highly aggressive cancer. Recent studies have revealed that TERRA (telomere repeat-containing RNA) acts to initiate ALT-associated HDR (ALT-HDR). ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD035943 | Pride
Cancer Alt Terra Homology-directed repair Chromatin Transcription Telomere Rad51ap1 
GenomicsNR2C/F orphan receptors induce telomere-genome rearrangements in ALT
Most sarcomas have complex karyotype and are characterized by multiple chromosomal rearrangements. Moreover, sarcomas very frequently maintain their telomeres by recombination in the process called Alternative Lengthening of Telomeres (ALT) which enables their continuous growth and immortalization. ...
ORGANISM(S): Homo sapiens 
2015-02-23 | E-GEOD-46237 | biostudies-arrayexpress
ProteomicsTRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
An inability to replicate the genome can cause replication stress and genome instability. Here, we develop BLOCK-ID, a proteomic method to identify and visualize proteins at stressed replication forks. This approach successfully identified novel mediators of the replication stress response, includin...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD063658 | Pride
Trim24  block-id  replication stress  alt  telomeres  sumoylation 
TranscriptomicsComparative analysis of RNA-seq data from human ALT+ cell lines treated with NR2F2 siRNA
The Alternative Lengthening of Telomeres (ALT) facilitates telomere lengthening by a DNA strand invasion and copying mechanism. The nuclear receptor NR2F2 can bind to (TCAGGG)n variant repeats within telomeres and it has been proposed that this facilitates telomere interactions in ALT+ cells. Howeve...
ORGANISM(S): Homo sapiens 
2020-12-15 | E-MTAB-9599 | biostudies-arrayexpress
TranscriptomicsAnti-telomerase therapy provokes ALT and mitochondrial adaptive mechanisms
This SuperSeries is composed of the following subset Series: GSE35044: Expression profiles of Telomerase+ vs. ALT+ G3 Atm-/-TERT-ER T-cell lymphomas GSE35045: Genomic copy number profiling of different generations of Atm-/-TERT-ER T-cell lymphomas and associated resistant tumors following telomerase...
ORGANISM(S): Mus musculus 
2012-01-17 | E-GEOD-35046 | biostudies-arrayexpress
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