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TranscriptomicsRNA-seq of canine MDCK epithelial cell line compared to cell line overexpressing ERK2 or cell line with conditional activation of the ERK pathway
Using RNA-seq and canine MDCK epithelial cells, we analyzed mRNA expression profiles of cells overexpressing ERK2 and cells where the ERK pathway was activated for 24 hrs. For this purpose, three cell lines were used: parental MDCK cells, MDCK cells overexpressing FLAG-ERK2 or MDCK cells expressing ...
ORGANISM(S): Canis lupus familiaris 
2022-10-01 | E-MTAB-12132 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling Defines the Roles of ERK and p38 Kinases in Epidermal Keratinocytes
Epidermal keratinocytes respond to extracellular influences by activating cytoplasmic signal transduction pathways that change the transcriptional profiles of affected cells. To define responses to two such pathways, p38 and ERK, we used SB203580 and PD98059 as specific inhibitors, and identified th...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-50591 | biostudies-arrayexpress
ProteomicsProtein abundance of AKT and ERK pathway components governs cell-type-specific regulation of proliferation
Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell-cycle progression, is poorly understood. Here we study different murine hematopoietic cell types, in which AKT and E...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080844 | MassIVE
ProteomicsContext-dependent regulatory mechanisms control site-specific information processing within the MEK/ERK module
The impact of the cellular context and receptor type on the dynamics of phosphorylation cycles in signaling pathways are unclear. We employ an unbiased approach to identify network alterations that explain phosphorylation dynamics of the MEK/ERK module in response to hepatocyte growth factor or inte...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080803 | MassIVE
TranscriptomicsCritical requirement of ERK/MAPK signaling in respiratory tract development
The mammalian genome contains two ERK/MAP kinase kinase genes, Mek1 and Mek2, which encode dual-specificity kinases responsible for ERK/MAP kinase activation. To define the function of ERK/MAPK signaling pathway in lung development, we performed tissue-specific deletions of Mek1 function in a Mek...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-51643 | biostudies-arrayexpress
TranscriptomicsTesticular lumicrine factors regulate ERK, STAT and NFKB pathways in the initial segment of the rat epididymis to prevent apoptosis
The initial segment of the epididymis is vital for male fertility, therefore, it is important to understand the mechanisms that regulate this important region. Deprival of testicular luminal fluid factors/lumicrine factors from epididymis, a subset of cells within the initial segment undergo apoptos...
ORGANISM(S): Rattus norvegicus 
2011-03-11 | E-GEOD-21806 | biostudies-arrayexpress
TranscriptomicseHSP70 promotes osteogenesis of hMSCs through activating ERK signaling pathway
Heat shock proteins are highly conserved proteins that, when produced intracellularly, protect stress exposed cells. It has been suggested that extracellular Hsp70 has both protective and deleterious effects. Our study showed eHSP70 increased the ALP activity, promoted mineralization and up-regulate...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-71080 | biostudies-arrayexpress
TranscriptomicsERK Oscillation-Dependent Gene Expression Patterns and Deregulation By The Stress-Response
Studies were undertaken to determine whether oscillatory behavior in the extracellular signal regulated kinase (ERK) pathway results in unique gene regulation patterns. Microarray analysis was performed on three subcloned populations of human keratinocytes with distinct ERK signaling/oscillation ph...
ORGANISM(S): Homo sapiens 
2014-03-13 | E-GEOD-55823 | biostudies-arrayexpress
ProteomicsVariable Thresholds for Phosphorylation Targets of the ERK Signaling Pathway
Cell fates regulated by ERK/MAP kinases respond to different thresholds of signaling strength. In mammalian cells, conditions that activate ERK to submaximal levels are sufficient for proliferation, survival and transformation, while stimuli that activate ERK to very high levels often lead to cell d...
ORGANISM(S): Homo Sapiens 
2026-02-25 | PXD070673 | panorama
ProteomicsSoluble SORLA enhances neurite outgrowth and regeneration through activation of EGFR and MAPK pathways
SORLA is a type I transmembrane component associated with Alzheimers disease (AD) risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain yet unclear. Here, we show that cultured neurons overexpressing SORLA (SORLA TG) feature enhanced neurite length, and accele...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-05-12 | MSV000085400 | MassIVE
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