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TranscriptomicsERK1/2 in Ovarian Granulosa Cells are Essential for Female Fertility
A surge of luteinizing hormone (LH) from the pituitary gland triggers ovulation, oocyte maturation, and luteinization for successful reproduction in mammals. Since the signaling molecules RAS and ERK1/2 are activated by a LH surge in granulosa cells of preovulatory follicles, we disrupted Erk1/2 in ...
ORGANISM(S): Mus musculus 
2009-03-20 | E-GEOD-15315 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse WT Erk1 and Erk2 deficient CD8 T cells
Comparison of unstimulated and in vitro activated wild type and Erk1 or Erk2 deficient CD8 T cells
ORGANISM(S): Mus musculus 
2008-10-07 | E-MEXP-1833 | biostudies-arrayexpress
TranscriptomicsDepletion of Erk1 and Erk2 MAP kinases in primary human keratinocytes
We assessed the effect of RNAi-mediated MAP kinase cascade signaling blockade in primary human keratinocytes. Two sets of siRNA targeting different regions of the Erk1/2 genes were used, enabling identification of off-target siRNA effects. Primary human keratinocytes were electroporated with scra...
ORGANISM(S): Homo sapiens 
2009-05-03 | E-GEOD-15417 | biostudies-arrayexpress
TranscriptomicsExpression data from mesothelial (LP9) and mesothelioma cells (HMESO) inhibited for extracellular-regulated kinase (ERK) 1, 2, or 5
Extracellular-regulated kinases (ERK1/2 and 5) are known to play important roles in growth and drug resistance of various cancers. Here we show roles of inhibition of ERK1, ERK2, or ERK5 on gene expression profiles of epithelioid malignant mesothelioma (MM) cells (HMESO). Untransfected human mesothe...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-21750 | biostudies-arrayexpress
TranscriptomicsDual-mechanism ERK1/2 inhibitors exploit a distinct binding mode to block phosphorylation and nuclear accumulation of ERK1/2, resulting in enhanced potency
Here we have characterized the MoA of Erk inhibitors in terms of Erk1/2 signalling, gene expression and antiproliferative efficacy in BRAF and RAS mutant cell lines.
ORGANISM(S): Homo sapiens 
2020-10-08 | E-MTAB-7959 | biostudies-arrayexpress
ProteomicsIdentification of ERK1 direct substrates using stable isotope labeled kinase assay linked phosphoproteomics
Following the kinase assay linked phosphoproteomics strategy (KALIP) (Xue, L et al., 2012), we used extracellular signal-regulated kinases 1 (ERK1) to phosphorylate the HEK293 cell lysate under the in vitro kinase assay condition. The phosphorylated proteins were then isolated and identified by mass...
ORGANISM(S): Homo sapiens (Human) 
2014-07-17 | PXD000357 | Pride
Erk1 Phosphoproteomics Kinase substrates 
TranscriptomicsTPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production [Set 1]
Analysis of Mtb infected murine macrophages derived from C57Bl/6 WT, TPL2KO, IFNARKO & TPL2IFNAR DKO mice [Set 1] Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality and morbidity worldwide, causing approximately 1.4 million deaths per year. Key immune comp...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-47672 | biostudies-arrayexpress
TranscriptomicsTPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production [Set 2]
Analysis of Mtb infected murine macrophages derived from C57Bl/6 WT, TPL2KO, IFNARKO & TPL2IFNAR DKO mice [Set 2] Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality and morbidity worldwide, causing approximately 1.4 million deaths per year. Key immune com...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-47673 | biostudies-arrayexpress
GenomicsRNA-sequencing analysis of mouse liver with a global ERK1, hepatocyte-specific ERK2 or double ERK1/2 knockout
RNA-sequencing analysis of mouse liver with a global ERK1, hepatocyte-specific ERK2 or double ERK1/2 knockout
PRJNA753503 | ENA
ProteomicsSCAMP3-Driven Regulation of ERK1/2 and Autophagy Phosphoproteomics Signatures in Triple-Negative Breast Cancer
Despite the promise of ERK1/2 pathway inhibitors, their efficacy is often limited by feedback mechanisms and pathway adaptability, emphasizing the need to identify co-regulatory proteins that modulate ERK1/2 signaling. Previously, we identified secretory carrier membrane protein 3 (SCAMP3) as a key ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD064784 | Pride
Proteomics Scamp3  triple negative breast cancer  erk1/2  autophagy  akt/mtor 
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