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N-3 polyunsaturated fatty acids (PUFAs) may prevent retinal vascular abnormalities observed in oxygen-induced retinopathy, a model of retinopathy of prematurity (ROP). In the OmegaROP prospective cohort study, we showed that preterm infants who will develop ROP accumulate the n-6 PUFA arachidonic...

2022-09-07 | MTBLS4219 | MetaboLights
This collection contains microRNA expression profiling data for samples purified from umbilical cord blood, belonging to one of the followiing populations: MEP, MEGA1, MEGA2, ERY1, ERY2, ERY3. MEP: megakaryocyte-erythrocyte precursors (defined by CD34+ CD38+ IL-3Ra- CD45RA- ); MEGA1: megakaryocyte p...
ORGANISM(S): Homo sapiens 
Diamond Blackfan Anemia (DBA) is a rare, congenital erythrocyte aplasia that is usually caused by haploinsufficiency of ribosomal proteins due to diverse mutations in one of several ribosomal protein genes. A striking feature of this disease is that a range of different mutations in ribosomal prote...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002339 | Pride
Polycythemia vera (PV) is a myeloproliferative disorder arising in pluripotent stem cells that causes an abnormal erythrocyte mass. More than 90% of PV patients have a mutation in JAK2 protein that is closely associated with the erythrocyte membrane. We report findings on quantitative analysis of th...
ORGANISM(S): Homo sapiens (Human) 
2015-05-11 | PXD001532 | Pride
Cholesterol-rich microdomains are membrane dynamic compartments characterized by specific lipid and protein composition and present in all cell types. These assemblies are involved in several biological processes, including infection by intracellular pathogens. This work provides a comprehensive ana...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-05 | MSV000086413 | MassIVE
We employed high-throughput sequencing of both short (~18-24nt) and long (>200nt) RNAs in human erythrocytes. We obtained blood from five healthy individuals for the short (small) RNA-seq library preparations and blood from three individuals for the long RNA-seq library preparations. We identified a...
ORGANISM(S): Homo sapiens 
The high prevalence of sickle cell disease in some human populations likely results from the protection afforded against severe Plasmodium falciparum malaria and death by heterozygous carriage of HbS. P. falciparum remodels the erythrocyte membrane and skeleton, displaying parasite proteins at the e...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2021-04-19 | PXD023280 | Pride
This file contains the models, simulation, and generated data that were used in the manuscript "Erythrocyte Metabolism". The equations used to create the models were derived from the paper by Dash et al. 2016 (doi: 10.1007/s00421-015-3228-3). The equations used to calculate the capillary erythrocyte...
2024-04-29 | MODEL2305140001 | BioModels
Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In P. falciparum, resistance is known to arise through genome-level changes such as mutations and gene duplications. We now report an epigenetic resistance mechanism involving genes...
ORGANISM(S): Plasmodium falciparum 
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